日本住友化学 SUMICHIRAL色谱柱 OA-SHELL P1
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Core-shell type chiral stationary phase
SUMICHIRALTM OA-SHELL P1
Advantages
SUMICHIRALTM OA-SHELL P1 is our first chiral stationary phase using optical active polymer. It is effective for chiral separation of compounds without amino group or carboxyl group，which are generally difficult to separate with conventional chiral stationary phases. Especially, it shows excellent resolution for aromatic chiral alcohol compounds. Core‐shell silica is used as a support and coated with poly (diphenylacetylene) derivative (optically active spiral polymer).
【Advantages of SUMICHIRALTM OA-SHELL P1】
Chiral stationary phase using core-shell silica support
★ Analysis time could be shortened with conventional HPLC ★
- Effective for chiral separation of compounds without amino group or carboxyl group ★
- Easy method development with simple mobile phase compositions ★
- Excellent durability, lot-to-lot repeatability ★
Unlike full porous particles, the core-shell particle has a non-porous core in the center and a thin porous layer outside of the core.
【Method development 】
SUMICHIRALTM OA-SHELL P1 makes it easy to set the conditions of mobile phase. The scheme of the general method development is shown in the right figure. For neutral compounds such as aromatic alcohols, it is not usually necessary to add special modifiers. For acidic compounds, add trifluoroacetic acid.
- Do not use the following solvents as they will cause the column to deteriorate : tetrahydrofuran, 1,2-dichloroethane, chloroform, ethyl acetate, acetone, etc.
Standard mobile phase n-hexane/2-propanol（95/5）
Change the concentration of 2 -propanol and adjust the retention time
（concentration of 2-propanol 0～20％）
Change 2-propanol to ethanol
（concentration of ethanol 0～10％）
For acidic compounds etc., add trifluoroacetic acid
| 【Durability test】 | （concentration of trifluoroacetic acid | 0.02～0.1％） | |
SUMICHIRALTM OA-SHELL P1 has excellent durability despite the use of optically active polymers as chiral selectors. The mobile phase was continuously fed to the column, and the stability was evaluated under the following conditions. As a result, almost no change was observed in separation factor, resolution, retention time, and column pressure.
Conditions
mobile phase：n-hexane / ethanol（95/5）
flow rate：0.2 ｍL/min detection：UV254 nm
column temperature：25℃
sample：trans-2-phenyl-1-cyclohexanol 10
Ordering information
【Specification of SUMICHIRALTM OA-SHELL P1】
| chiral selector | core-shell silica support | ||||
| particle size | pore size | specific surface area | |||
| poly (diphenylacetylene) | 2.6 μm | 250～280Å | 40～60 m2/g | ||
| derivative | |||||
| 【List of SUMICHIRALTM OA-SHELL | P1】 | ||||
| particle size | internal diameter | column length | P/N | ||
| （μｍ） | （mm） | （mm） | |||
| 50 | C-SP01-3005W | ||||
| 2.6 | 3.0 | 100 | C-SP01-3010W | ||
| 150 | C-SP01-3015W | ||||
【List of guard filter】
For column protection, we recommend porous glass guard filter “SUMIPAXTM Filter PG-ODS for semi-micro “.
| product name | contents | P/N | |||
| SUMIPAXTM Filter Starter kit PG-ODS | SUS holder | 1 pcs | GMODS001 | ||
| for semi-micro | filter 1 pcs | ||||
| SUMIPAXTM Filter PG-ODS | replacement filter 8 pcs | GMODS002 | |||
| Replacement filter | for semi-micro | ||||
| SUMIPAXTM Holder | for semi-micro | SUS holder | 1 pcs | GMACC001 | |
| Connection kit for semi-micro | ferrule screw | 2 pcs | GMACC002 | ||
| SUS tube | 1 pcs | ||||
【Column selection】
There are many kinds of SUMICHIRALTM series columns, so it is important to select the optimum column depending on the target compounds. Since you can use the database of chiral applications on our website and search application data from compound names and functional group information, please refer to the column selection.
- SUMICHIRALTMand SUMIPAXTM are registered trademarks in Japan.
- For prices and column sizes other than the above, please contact our distributor.