HSP90AB1 Mouse Monoclonal Antibody [Clone ID: OTI4C10]HSP90AB1 小鼠单克隆抗体 [克隆 ID： OTI4C10]

发表于由
 Product Data
Clone Name OTI4C10
Applications WB
Recommend Dilution WB 1:2000
Reactivity Human, Monkey, Mouse, Rat, Dog
Host Mouse
Clonality Monoclonal
Immunogen Full-length protein expressed in 293T cell transfected with human HSP90AB1 expression vector
Isotype IgG2b
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 83.3 kDa
Gene Name heat shock protein 90 alpha family class B member 1
Background HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219)
 Reference Data
Protein Families Druggable Genome, Stem cell – Pluripotency
Protein Pathways Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

The use of this Antibodies has been cited in the following citations:
An Exploratory Analysis of Extracellular Vesicle-Associated and Soluble Cytokines in Cancer-Related Fatigue in Men with Prostate Cancer. ,Sass, D;Fitzgerald, W;Barb, J;Kupzyk, K;Margolis, L;Saligan, L;, Brain, Behavior, & Immunity – Health 2020 [HSP90AB1]
Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy ,Hossain, M;Williams, S;Ferguson, L;Bingaman, W;Ghosh, A;Najm, IM;Ghosh, C;, Mol. Neurobiol. 2020 ,PubMed ID 32748370 [HSP90AB1]
LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway ,Li, HK;Zhou, Y;Ding, J;Xiong, L;Shi, YX;He, YJ;Yang, D;Deng, ZL;Nie, M;Fei Gao, Y;, Exp. Cell Res. 2020 ,PubMed ID 32841643 [HSP90AB1]
Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas ,Florkowska, A;Meszka, I;Zawada, M;Legutko, D;Proszynski, TJ;Janczyk-Ilach, K;Streminska, W;Ciemerych, MA;Grabowska, I;, Stem Cell Res Ther 2020 ,PubMed ID 32552916 [HSP90AB1]
In-Vitro-Generated Hypertrophic-Like Adipocytes Displaying PPARG Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo ,Aprile, M;Cataldi, S;Perfetto, C;Ambrosio, MR;Italiani, P;Tatè, R;Blüher, M;Ciccodicola, A;Costa, V;, Cells 2020 ,PubMed ID 32455814 [HSP90AB1]
Superoxide Dismutases SOD1 and SOD2 Rescue the Toxic Effect of Dopamine-Derived Products in Human SH-SY5Y Neuroblastoma Cells ,Biosa, A;De Lazzari, F;Masato, A;Filograna, R;Plotegher, N;Beltramini, M;Bubacco, L;Bisaglia, M;, Neurotox Res 2019 ,PubMed ID 31228093 [HSP90AB1]
Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage ,Pond, KW;de Renty, C;Yagle, MK;Ellis, NA;, PLoS Genet. 2019 ,PubMed ID 30735491 [HSP90AB1]
Segmented poly(A) tails significantly reduce recombination of plasmid DNA without affecting mRNA translation efficiency or half-life ,Trepotec, Z;Geiger, J;Plank, C;Aneja, MK;Rudolph, C;, RNA 2019 ,PubMed ID 30647100 [HSP90AB1]
Tamoxifen therapy in a murine model of myotubular myopathy ,Maani, N;Sabha, N;Rezai, K;Ramani, A;Groom, L;Eltayeb, N;Mavandadnejad, F;Pang, A;Russo, G;Brudno, M;Haucke, V;Dirksen, RT;Dowling, JJ;, Nat Commun 2018 ,PubMed ID 30451841 [HSP90]
Chromatin regulates IL-33 release and extracellular cytokine activity ,Travers, J;Rochman, M;Miracle, CE;Habel, JE;Brusilovsky, M;Caldwell, JM;Rymer, JK;Rothenberg, ME;, Nat Commun 2018 ,PubMed ID 30108214 [HSP90AB1]
MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1 ,Liang, W;Liao, Y;Li, Z;Wang, Y;Zheng, S;Xu, X;Ran, F;Tang, B;Wang, Z;, Cell Commun. Signal 2018 ,PubMed ID 29898735 [HSP90AB1]
Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells ,Ghosh, A;Garee, G;Sweeny, EA;Nakamura, Y;Stuehr, DJ;, Proc. Natl. Acad. Sci. U.S.A. 2018 ,PubMed ID 29358373 [HSP90AB1]
IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis ,Travers, J;Rochman, M;Caldwell, JM;Besse, JA;Miracle, CE;Rothenberg, ME;, Sci Rep 2017 ,PubMed ID 29242581 [HSP90AB1]
Myogenic potential of mouse embryonic stem cells lacking functional Pax7 tested in vitro by 5-azacitidine treatment and in vivo in regenerating skeletal muscle ,Helinska, A;Krupa, M;Archacka, K;Czerwinska, AM;Streminska, W;Janczyk-Ilach, K;Ciemerych, MA;Grabowska, I;, Eur. J. Cell Biol 2016 ,PubMed ID 28017376 [HSP90AB1]
Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7 ,Czerwinska, AM;Nowacka, J;Aszer, M;Gawrzak, S;Archacka, K;Fogtman, A;Iwanicka-Nowicka, R;Janczyk-Ilach, K;Koblowska, M;Ciemerych, MA;Grabowska, I;, Cell Cycle 2016 ,PubMed ID 27610933 [Hsp90]