| Product Data | |
| Clone Name | OTI2G7 |
| Applications | IF, WB |
| Recommend Dilution | WB 1:2000, IF 1:50 |
| Reactivity | Human, Monkey, Mouse, Rat, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human PCNA (NP_002583) produced in E.coli. |
| Isotype | IgG2b |
| Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 28.6 kDa |
| Gene Name | proliferating cell nuclear antigen |
| Background | The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008] |
| Reference Data | |
| Protein Families | Druggable Genome, Stem cell – Pluripotency |
| Protein Pathways | Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair |
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