Harlan AIN diet formulas

Harlan AIN diet formulas

Harlan Teklad动物饲料

Harlan代理

欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。

These formulas are purified diets with commonly used refined ingredients. These basic formulas are often modified for a specific research purpose, such as altering the fat source, a vitamin or mineral level, or adding a compound. See the FAQ section to learn more about the history of these formulas, AIN-76A, AIN-93G, and AIN-93M.

  • CA.170481 AIN-76A purified diet
  • TD.94045 AIN-93G purified diet
  • TD.94048 AIN-93M purified diet

These formulas (as well as other purified diets) do not contain alfalfa and can be used to reduce background autofluorescence in certain imaging applications. Our Global Rodent Diets are also alfalfa-free and are suitable for imaging work. Please contact us for further information about these formulas or modifications.

Other related product codes:

  • TD.94096 version of AIN-76A suitable for irradiation (vitamin levels are increased)
  • TD.97184 version of AIN-93G suitable for irradiation (vitamin levels are increased)
  • TD.00102 version of AIN-93M suitable for irradiation (vitamin levels are increased)
  • TD.95092 modification of AIN-93G where soybean oil is replaced with corn oil.

Harlan AIN diet formulas

这些配方是含有常用精制成分的纯正饮食。这些基本配方通常是为特定的研究目的而修改的,例如改变脂肪来源、维生素或矿物质水平,或添加一种化合物。见常见问题了解更多关于这些公式的历史的章节,AIN-76A,AIN-93g,和AIN-93m。

  • CA.170481AIN-76A纯饲料
  • TD.94045AIN-93g纯饲料
  • TD.9404893米纯饲料

这些配方(以及其他纯化饲料)不含苜蓿,可用于减少背景自荧光在某些成像应用中。我们的全球啮齿动物饮食也是无苜蓿的,适合成像工作.有关这些公式或修改的进一步信息,请与我们联系。

其他相关产品代码:

  • TD.94096适合辐照的AIN-76A版本(维生素含量增加)
  • TD.97184适合辐照的an-93g版本(维生素含量增加)
  • TD.00102AIN-93m适合辐照的版本(维生素含量增加)
  • TD.95092用玉米油代替大豆油的n-93g改性。

Harlan Teklad Diet ingredients

Harlan Teklad Diet ingredients

Teklad diet, bedding and enrichment + Teklad laboratory animal diets + Custom research diets + Diet ingredients

You may want to prepare your own diet at your research site or facility, and if that is the case, you depend on the ingredients being of the highest quality. Envigo can provide you with many of the same ingredients used to produce our advanced Teklad custom research diets so you can develop your own formula. And as always, our nutritional experts are here to help you make the best decisions for your ingredients and ultimate formulation.

Our ingredients

We offer several ingredients for individual sale so that you can develop your own blends.

“VFT” casein

  • “Vitamin-free” test casein (alcohol-extracted) is best suited for purified test diet formulas where fat or vitamin content needs to be precisely controlled
  • The reduced levels of many vitamins in VFT casein make it the preferred protein source for many vitamin studies. Thus, the nickname “Vitamin-free” was given to the extracted casein many years ago

Vitamin mixes

  • The common vitamin mixes shown below use sucrose or corn starch as a carrier
  • Customized vitamin mixes may use cellulose if a non-nutritive carrier is necessary
  • Vitamin mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of your laboratory animal
  • For those preparing their own diets, vitamin premixes are an efficient way to add vitamins to a diet
  • Vitamin mixes should be stored at 4 degrees celsius or lower upon receipt. Storage at –20 degrees celsius is recommended if the mix will be used beyond 1 month
  • Minimum order is 500 g for both stock and custom vitamin mixes
  • Our available vitamin mixes are commonly used in diets, and are available from stock
  • Vitamin mixes are shipped within a few days of order

Our Formula examples

  • CA.40060 Teklad vitamin mix
  • CA.40077 AIN-76A vitamin mix
  • TD.94047 AIN-93 vitamin mix

Mineral mixes

  • The common mineral mixes shown below as examples use sucrose as a carrier
  • Customized mineral mixes could use cellulose or no carrier if a non-nutritive carrier is necessary
  • Our mineral mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of the animal
  • For those preparing their own diets, mineral premixes are an efficient way to add minerals to a diet
  • Mineral mixes should be stored in a dry cool environment and used within a year of receipt. The minimum order is 500 g for both stock and custom mineral mixes
  • These mineral mixes are commonly used in diets, and are available from stock
  • Our mineral mixes are shipped within a few days of order

Formula examples:

  • CA.170915 AIN-76 mineral mix
  • TD.94046 AIN-93G mineral mix
  • TD.94049 AIN-93M mineral mix

Other mixes (may or may not be available from stock):

  • TD.83171 Vitamin mix without A, D, E, choline
  • TD.81062 Iron deficient mineral mix based on AIN-76A
  • TD.79055 Calcium and phosphorus deficient mineral mixed based on AIN-76
  • TD.98057 Calcium and phosphorus deficient mineral mixed based on AIN-93
  • CA.170760 Rogers-Harper mineral mix

你可能想要在你的研究地点或设施准备你自己的饮食,如果是这样的话,你取决于成分是最高的质量。Envigo可以为您提供许多相同的成分,用于生产我们先进的特克拉德定制研究饮食,以便您可以开发自己的配方。和往常一样,我们的营养专家在这里帮助您为您的配料和最终配方做出最佳决定。

我们的配料

我们提供几个配料供个人销售,以便您可以开发自己的混合。

“VFT”酪蛋白

  • “无维生素”测试酪蛋白(酒精提取)最适合于那些需要精确控制脂肪或维生素含量的纯正试验饮食配方。
  • VFT酪蛋白中许多维生素含量的降低使得它成为许多维生素研究的首选蛋白质来源。因此,“无维生素”的绰号是在许多年前给提取出来的酪蛋白起的。

维生素混合物

  • 以下常见的维生素混合物使用蔗糖或玉米淀粉作为载体。
  • 定制的维生素混合物可能使用纤维素,如果非营养载体是必要的。
  • 维生素混合物的制定考虑到了饮食中的包容率。多用或少用会损害你的实验动物的健康。
  • 对于那些自己准备饮食的人来说,维生素预混剂是向饮食中添加维生素的一种有效方法。
  • 维生素混合物应储存在4摄氏度或更低的接收。如果使用时间超过1个月,建议使用摄氏-20度。
  • 库存和定制维生素混合物的最低订购量为500克。
  • 我们可用的维生素混合物通常用于饮食,并可从库存中获得。
  • 维生素混合物在订购后几天内发货。

我们的公式示例

  • CA.40060 特克拉德维生素混合物
  • CA.40077 AIN-76A维生素混合物
  • TD.94047 AIN-93维生素混合物

矿物混合物

  • 下面所示的常见矿物混合物是以蔗糖为载体的。
  • 如果需要非营养的载体,定制的矿物混合物可以使用纤维素,也可以不使用载体。
  • 我们的矿物质混合物是根据饮食包容率来制定的。多用或少用会损害动物的健康。
  • 对于那些自己准备饮食的人来说,矿物预混料是向饮食中添加矿物质的有效方法。
  • 矿物混合物应存放在干燥、凉爽的环境中,并在收到后一年内使用。库存和自定义矿物混合物的最低订购量为500克。
  • 这些矿物混合物通常用于饮食,并可从库存中获得。
  • 我们的矿物混合物在订货后几天内装运。

公式示例:

  • CA.170915 AIN-76矿物混合物
  • TD.94046 AIN-93g矿物混合物
  • TD.94049 AIN-9300万矿物混合物

其他混合材料(可能从库存中获得,也可能无法从库存中获得):

  • TD.83171不含A,D,E,胆碱的维生素混合物
  • TD.81062基于AIN-76A的缺铁矿物配料
  • TD.79055 AIN-76混合钙磷缺乏矿物
  • TD.98057AIN-93混合钙磷缺乏矿物
  • CA.170760 罗杰斯-哈珀矿物混合物

Harlan Teklad 2016 global 16% protein rodent diets

Harlan Teklad 2016 global 16% protein rodent diets

Product Features

  • Designed to support growth and maintenance
  • Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
  • Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
  • Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imagingclarity
  • Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)
Products
Teklad rodent diets Non-autoclavable form Autoclavable Irradiated
Teklad global 16% protein 2016, 2016C 2016S 2916
Not all products are stocked locally; extended lead time and additional fees may apply.
Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.

Teklad Global 16% Protein Rodent Diet

Product Description- 2016 is a fixed formula, non-autoclavable diet
manufactured with high quality ingredients and designed to support growth
and maintenance. 2016 does not contain alfalfa or soybean meal, thus
minimizing the occurrence of natural phytoestrogens. Typical isoflavone
concentrations (daidzein + genistein aglycone equivalents) range from nondetectable
to 20 mg/kg. Exclusion of alfalfa reduces chlorophyll, improving
optical imaging clarity. Absence of animal protein and fish meal minimizes
the presence of nitrosamines. Also available certified (2016C) and
irradiated (2916). For autoclavable diet, refer to 2016S (Sterilizable).

Macronutrients

Crude Protein % 16.4
Fat (ether extract) a % 4.0
Carbohydrate (available) b % 48.5
Crude Fiber % 3.3
Neutral Detergent Fiber c % 15.2
Ash % 4.9
Energy Density d kcal/g (kJ/g) 3.0 (12.6)
Calories from Protein % 22
Calories from Fat % 12
Calories from Carbohydrate % 66
Minerals    
Calcium % 1.0
Phosphorus % 0.7
Non-Phytate Phosphorus % 0.4
Sodium % 0.2
Potassium % 0.6
Chloride % 0.4
Magnesium % 0.2
Zinc mg/kg 70
Manganese mg/kg 100
Copper mg/kg 15
Iodine mg/kg 6
Iron mg/kg 200
Selenium mg/kg 0.23
Amino Acids    
Aspartic Acid % 1.0
Glutamic Acid % 3.3
Alanine % 0.9
Glycine % 0.7
Threonine % 0.6
Proline % 1.5
Serine % 0.8
Leucine % 1.9
Isoleucine % 0.7
Valine % 0.8
Phenylalanine % 0.9
Tyrosine % 0.5
Methionine % 0.3
Cystine % 0.3
Lysine % 0.8
Histidine % 0.4
Arginine % 0.8
Tryptophan % 0.2

Teklad Diets are designed and manufactured for research purposes only.

Ingredients (in descending order of inclusion)- Ground wheat, ground corn, wheat middlings, corn gluten meal, calcium carbonate, dicalcium phosphate, soybean oil, brewers dried yeast, iodized salt, L-lysine, DL-methionine, choline chloride, magnesium oxide, vitamin E acetate, menadione sodium bisulfite complex (source of vitamin K activity), manganous oxide, ferrous sulfate, zinc oxide, niacin, calcium pantothenate, copper sulfate, pyridoxine hydrochloride, riboflavin, thiamin mononitrate, vitamin A acetate, calcium iodate, vitamin B12 supplement, folic acid, biotin, vitamin D3 supplement,

cobalt carbonate.

Vitamins

Vitamin A e, f IU/g 15.0
Vitamin D3 e, g IU/g 1.5
Vitamin E IU/kg 110
Vitamin K3 (menadione) mg/kg 50
Vitamin B1 (thiamin) mg/kg 17
Vitamin B2 (riboflavin) mg/kg 15
Niacin (nicotinic acid) mg/kg 75
Vitamin B6 (pyridoxine) mg/kg 18
Pantothenic Acid mg/kg 33
Vitamin B12 (cyanocobalamin) mg/kg 0.08
Biotin mg/kg 0.40
Folate mg/kg 4
Choline mg/kg 1030
Fatty Acids    
C16:0 Palmitic % 0.5
C18:0 Stearic % 0.1
C18:1ω9 Oleic % 0.7
C18:2ω6 Linoleic % 2.0
C18:3ω3 Linolenic % 0.1
Total Saturated % 0.6
Total Monounsaturated % 0.7
Total Polyunsaturated % 2.1
Other    
Cholesterol mg/kg

 

  • Ether extract is used to measure fat in pelleted diets, while an acid hydrolysis method is required to recover fat in extruded diets. Compared to ether extract, the fat value for acid hydrolysis will be approximately 1% point higher.
  • Carbohydrate (available) is calculated by subtracting neutral detergent fiber from total carbohydrates.
  • Neutral detergent fiber is an estimate of insoluble fiber, including cellulose, hemicellulose, and lignin. Crude fiber methodology underestimates total fiber.
  • Energy density is a calculated estimate of metabolizable energybased on the Atwater factors assigning 4 kcal/g to protein, 9 kcal/g to fat, and 4 kcal/g to available carbohydrate.
  • Indicates added amount but does not account for contribution from other ingredients.
  • 1 IU vitamin A = 0.3 µg retinol
  • 1 IU vitamin D = 25 ng cholecalciferol

For nutrients not listed, insufficient data is available to quantify.

Nutrient data represent the best information available, calculated from published values and direct analytical testing of raw materials and finished product. Nutrient values may vary due to the natural variations in the ingredients, analysis, and effects of processing.

Harlan 啮齿类饲料 Rodent diets

Harlan 啮齿类饲料 Rodent diets

As a researcher, you want to have as much control as possible over what goes into your study animals. At Envigo, we understand that. That is why we developed Teklad Global Rodent Diets®.

Teklad Global Rodent Diets® are a special integrated range of vegetarian laboratory rodent diets developed to be nutritionally complete for various life stages from breeding through long-term maintenance. Global rodent laboratory diets contain levels of protein, energy, vitamins and minerals that are more appropriate to the needs of modern biomedical research studies.

Furthermore, in global rodent diets particular attention has been placed on avoiding, as far as practical, ingredients that are reported to have adverse confounding effects on experimental results. This has resulted in a range of Teklad rodent laboratory diets that contain:

No fish meal

No meat meals or meat by-products

No alfalfa meal

No soybean meal or reduced levels

No animal fat

By excluding animal by-products, the presence of nitrosamines (a potential carcinogen) is avoided. Exclusion of alfalfa meal reduces chlorophyll, improving optical imaging clarity. Reduction or removal of soybean meal, together with elimination of alfalfa meal, minimizes levels of naturally-occurring phytoestrogens. Phytoestrogens interact with endogenous estrogens and potentially can affect studies in many research areas. Read more about this in these pieces:

Dietary phytoestrogens, a source of research variation
Ask a Nutritionist Series: Impact of phytoestrogens on research, Volume 1

Phytoestrogens limit translation of preclinical results to clinical outcomes
Ask a Nutritionist Series: Impact of phytoestrogens on research, Volume 2

Products
Teklad rodent diets Non-autoclavable form Autoclavable Irradiated
Teklad global 14% protein 2014, 2014C 2014S 2914
Teklad global 16% protein 2016, 2016C 2016S 2916
Teklad global 18% protein 2018, 2018C 2018S, 2018SX 2918
Teklad global 19% protein extruded 2019 2019S 2919
Teklad global soy protein-free extruded 2020X 2020SX 2920X
Traditional diets see more
Not all products are stocked locally; extended lead time and additional fees may apply.
Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.
产品
Teklad啮齿类食物 不可蒸压式 高压釜 辐照
总蛋白14% 2014 2014C 2014S 2914
总蛋白16% 2016 2016C 2016S 2916
Teklead全局18%蛋白 2018 2018C 2018S,2018SX 2918
Teklad 19%蛋白挤出 2019 2019S 2919
Teklad 无大豆蛋白挤出 2020 X 2020SX 2920 X
传统饮食 见更多
并不是所有的产品都是在当地库存的,可能需要延长交货期和额外的费用。

Traditional rodent diets were formulated decades ago based on understanding of rodent nutrition, ingredients, and diet manufacturing at the time. While traditional diets will supply the known nutrient needs of your laboratory animals, we recommend you consider the use of a diet from our newer global diet line for your modern research needs.

Teklad Global Rodent Diets® are modern formulas designed to reduce research variables. Specifically, these diets contain more appropriate nutrient levels, and limit or exclude ingredients that are reported to have effects on a wide variety of research endpoints.

  • Lower, more appropriate protein levels can improve survival and reduce morbidity
  • Vegetarian with no nitrosamines (a potential carcinogen)
  • Formulated to exclude alfalfa meal, greatly improving fluorescent imaging clarity
  • Formulated to exclude or lower soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
  • Extruded rodent diets dramatically reduce clumping and hardness after autoclaving (2018SX, 2019S, 2020SX), and in general result in less diet waste and cleaner cages

Teklad rodent diets are natural-ingredient diets specifically formulated to provide the proper balance of all known nutrients considered essential for the growth, maintenance, and reproduction of rats, mice, gerbils and hamsters. These diets conform to the nutrient requirements for rodents established by the National Research Council (1995).

Teklad rodent diets provide uniform nutrition. They are fixed-formula diets designed to minimize the nutrient variances which otherwise could occur if the ingredient composition of a diet were altered from one batch to the next.

Protein is supplied primarily by plant sources. Supplemental amino acids are added to provide the proper amount and balance of essential amino acids. All rodent diets are fortified with vitamins and minerals to help support the regulation of body fluids and the proper functioning of body systems to ensure the adequate growth, maintenance, and reproduction of research rodents. Autoclavable diets are supplemented with additional vitamins to compensate for losses that occur during autoclaving. Since our diets are nutritionally complete and balanced, it is not necessary to add dietary supplements.

There is no definitive point where one is able to predict when a specific diet will spoil or become deficient in one or more nutrients. The common guideline of a six month shelf life is based on longstanding practice in North America. In Europe and Asia, differences in local practices and regulatory oversight have led to Teklad standard natural ingredient diets being routinely used out to nine months and sometimes 12 months post-manufacture. This practical experience, along with literature support and vitamin testing over time, gives us confidence that these diets continue to support animal health and study integrity out to at least nine months post-manufacture. Please refer to your institution for guidance if you are unsure of local policies.

Recommended storage conditions:

  • Cool and dry; at or below 70 degrees fahrenheit with humidity ideally below 50%, but up to 65% is acceptable
  • Clean and free of pests
  • In original packaging or in a container that prevents continuous exposure to light and minimal exposure to air

Standard natural ingredient rodent diets are complete diets for rats, mice, gerbils and hamsters, that should be allowed ad libitum access to the diet. Fresh water should be available at all times.

Harlan TD.88137 高酯饲料Adjusted calories diet (42% from fat)说明书

Harlan TD.88137 高酯饲料Adjusted calories diet (42% from fat)说明书

Harlan Teklad代理,Harlan Teklad一级代理,欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。

A staple of atherosclerosis research

More than 25 years ago, our nutritionists collaborated with researchers at Rockefeller University to develop a diet with features of a ‘Western Diet’ to characterize and enhance atherosclerosis development in their newly generated Apoe deficient mouse model.

With over 200 unique users worldwide, TD.88137 continues to be fed to genetically modified cardiovascular models to accelerate and enhance hypercholesterolemia and plaque formation.

Formula g/Kg
Casein 195.0
DL-Methionine 3.0
Sucrose 341.46
Corn Starch 150.0
Andydrous Milkfat 210.0
Cholesterol 1.5
Cellulose 50.0
Mineral Mix, AIN-76 (170915) 35.0
Calcium Carbonate 4.0
Vitamin Mix, Teklad (40060) 10.0
Ethoxyquin 0.04

Selected nutrient information1

  % By weight % kcal from
     
Protein 17.3 15.2
Carbohydrate 48.5 42.7
Fat 21.2 42.0
     
kcal/g 4.5  
Cholesterol2 0.2%  
  • Values are calculated from ingredient analysis or manufacturer data.
  • 15% added, 0.05% from fat source.

Critical dietary features of TD.88137 related to atherosclerosis development include:

++Cholesterol (0.2% total cholesterol)

++Total fat (21% by weight; 42% kcal from fat)

++High in saturated fatty acids

(>60% of total fatty acids)

++High sucrose (34% by weight)

Typical fatty acid profile of TD.88137

Typical fatty acid analysis, Mean SD  
% of diet1  
     
Total 20.7 1.5  
Saturated fat 12.8 0.8  
Monounsaturated fat 5.6 0.5  
Polyunsaturated fat 1.0 0.2  
Unknown2 1.3 0.3  
       
Typical fatty acid profile, Mean SD  
% of total fatty acids1  
     
Saturated fat 61.8 2.0  
Monounsaturated fat 27.3 2.1  
Polyunsaturated fat 4.7 0.8  
4:0 2.1 1.1  
6:0 1.5 0.7  
8:0 1.1 0.3  
10:0 2.6 0.5  
12:0 3.3 0.5  
14:0 10.6 0.9  
16:0 28.9 1.3  
16:1 1.5 0.2  
18:0 12.5 0.8  
18:1 (Oleic) 20.9 2.6  
18:1 Isomers3 4.0 1.2  
18:2 (Linoleic) 2.3 1.0  
18:2 Isomers4 1.3 0.5  
18:3 (Linolenic) 0.7 0.2  
  • n = 21, analysis conducted by two independent laboratories.
  • Unidentified fatty acids and those contributing on average less than 0.5% of total fatty acids.
  • Includes trans isomers elaidic and vaccenic acid and unidentified cis isomers.
  • Includes trans isomers.

Key points from the literature

TD.88137 has been used to accelerate atherosclerosis development in Apoe and Ldlr deficient models:

++In Apoe deficient mice, plasma cholesterol triples to >1500 mg/dL within three weeks (1, 2). Foam cell and lesion development occurs within 6-10 weeks (2-4). Fibrous plaque formation is observed at 15 weeks with the development of fibrous caps after 20 weeks (2).

++Ldlr deficient mice fed for two weeks increase plasma cholesterol to >800 mg/dL and triglyceride to >300 mg/dL (5). After six weeks of feeding, hyperglycemia, hyperinsulinemia and dyslipidemia develop with small foam cell lesions in the aortic arch (6, 7).

For further information about TD.88137, or if you are interested in learning more about other atherogenic or high fat diets contact us at

With over 420 citations, uses of TD.88137 continue to evolve and include atherosclerosis, obesity, non-alcoholic steatohepatitis (NASH), osteoporosis, hypertension and metabolic syndrome. Contact us for a more extensive reference list.

Control diet options for TD.88137

Natural ingredient diets

++Also referred to as standard diets or chow

++Diets differ in the source and level of nutrients as well as the presence of non-nutritive factors (such as phytates or phytoestrogens) compared to TD.88137

++Limits inferences to differences in dietary pattern versus a specific dietary component

Ingredient matched, low fat diets

++Controls for the type of ingredients, non-nutritive components and the source and level of specific nutrients

++Suggested ingredient matched, low fat dietary controls for TD.88137 listed below; data sheets can be found on our website at

Suggested ingredient matched, low fat controls

Diet kcal/g Fat, % by % kcal Fat sources, Sucrose, %
    weight from fat % by weight by weight
        3.7% milk fat,  
TD.05230 3.7 5.2 12.6 1.3% soybean 34.1
        oil  
           
        3.7% milk fat,  
TD.08485 3.6 5.2 13.0 1.3% soybean 12.0
        oil  
           

Additional controls are available. Contact a nutritionist at

Key planning information:

  • Store diet refrigerated and plan to use within six months. Diet should be replaced at minimum once per week when fed on cage tops.
  • Diets available as a soft ½” pellet or as a crumbly powder.
  • Three kg minimum order quantity. For planning purposes, estimates for diet uses (including feed intake and diet waste) are 5 g of diet per mouse and 30 g of diet per rat per day.
  • Two-day lead time for orders less than 10 kg. Two-week lead time for larger quantity orders.
  • Lead time for irradiation adds two weeks for any quantity of diet and must be requested at the time you place your order. Changes in texture and browning may occur with irradiation.
  • Shipping can affect pellet quality. Vacuum packaging can offer protection of the pellets during shipping. Two-day shipping is recommended during warmer months.

Contact us to place an order,

References

  1. Plump, A.S., et al.,Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell, 1992. 71(2): p. 343-53.
  2. Nakashima, Y., et al.,Apoe-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb, 1994. 14(1): p. 133-40.
  3. Febbraio, M., et al.,Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice.

J Clin Invest, 2000. 105(8): p. 1049-56.

  1. Nakashima, Y., et al.,Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the Apoe-deficient mouse. Arterioscler Thromb

Vasc Biol, 1998. 18(5): p. 842-51.

  1. Towler, D.A., et al.,Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice.

J Biol Chem, 1998. 273(46): p. 30427-34.

  1. Tsuchiya, K., et al.,FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab, 2012. 15(3): p. 372-81.
  2. Huszar, D., et al.,Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler Thromb Vasc Biol, 2000. 20(4): p. 1068-73.
  3. Yang, B., et al.,Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats. Biochem Biophys Res Commun, 2006. 341(1): p. 209-17.
  4. Schafer, K., et al.,Leptin promotes vascular remodeling and neointimal growth in mice. Arterioscler Thromb Vasc Biol, 2004. 24(1): p. 112-7.
  5. Lijnen, H.R., et al.,Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol, 2003. 23(1): p. 78-84.
  6. Maquoi, E., et al.,Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes, 2002. 51(4): p. 1093-101.
  7. VanSaun MN, et al. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol 175:355-64.
  8. Dixon LJ, et al. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One 8:e56100.

Harlan Teklad动物饲料分类

Harlan Teklad动物饲料分类

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Standard natural ingredient diets  标准天然成分饮食

  • Rodent diets  啮齿类食物
  • Dog diets  狗粮
  • Rabbit diets   兔饲料
  • Guinea pig diets    豚鼠日粮
  • Primate diets  灵长类饮食
  • Swine diets  猪日粮
  • Other diets

Custom research diets  定制研究饮食

  • Ordering and services  订购和服务
  • NAFLD and NASH    NAFLD和NASH
  • AIN diet formulas   AIN饮食配方
  • Atherogenic    动脉粥样硬化

Atherogenic

Diet can be a useful tool to induce or accelerate atherosclerosis in laboratory animal models. Key dietary features used to induce atherosclerosis in rodents vary depending on the research model, desired endpoint, and length of feeding. While formulations of atherogenic diets continue to evolve, the options that are well-described in the literature are summarized below. For more information on each diet option and literature references see the expandable tabs following the diet table.

Research use Key dietary features Examples
“Western” purified atherogenic diet
Accelerated hypercholesterolemia and plaque formation in genetically modified models such as Apoe and Ldlr deficient mice.

Used for diet induced obesity in a variety of rodent models.

  • High fat diet (20 – 23% by weight; 40 – 45% kcal from fat)
  • Saturated fatty acids (SFA >60% of total fatty acids)
  • Milkfat/butterfat
  • Sucrose (34% by weight)
  • Cholesterol (0.2% total)
TD.88137
TD.10885
“Western” purified atherogenic diet with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.

Will not promote obesity.

  • High fat diet (15 – 20% by weight; 34 – 45% kcal from fat)
  • Saturated fatty acids (SFA >55% of total fatty acids)
  • Milkfat/butterfat, cocoa butter
  • Sucrose (30-50% by weight)
  • Cholesterol (1 – 1.25%)
  • Cholate Source (0.5%)*
TD.02028
TD.09237
Hybrid high fat diets with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.

Will not promote obesity.

Also used for lithogenic (gallstone) rodent studies.

  • 75% rodent breeder diet; 25% purified ingredients
  • High fat (~15% by weight; 37% kcal from fat)
  • Saturated fatty acids (SFA >45% of total fatty acids)
  • Cholesterol (1.25%)
  • Cholate source (0.5%)*
TD.88051
TD.90221
Standard diets with added cholesterol
Induce hypercholesterolemia in genetically modified and wild type models without promoting obesity.
  • Standard, grain-based rodent diet
  • Minimal/moderate phytoestrogen diets recommended
  • Cholesterol (1 – 4%)
TD.120097
TD.07841
TD.01383

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available.

  • Diet induced obesity    饮食诱导肥胖
  • Fat/lipid adjusted   脂肪/脂调节
  • Carbohydrate adjusted    碳水化合物调节
  • Protein adjusted diets  蛋白质调节饮食
  • Vitamin adjusted diets  维生素调整饮食
  • Mineral adjusted diets  矿物调节饮食
  • NaCl adjusted (natural ingredient)  盐调节(天然成分)
  • Amino acid defined  氨基酸定义
  • Doxycycline diets  多西环素饮食
  • Tamoxifen diets  他莫昔芬饮食
  • Customer supplied ingredients  客户供应的配料
  • Basal mixes  基混合体
  • Isoflavone adjusted  异黄酮调节
  • Rabbit, swine and other species  兔子、猪和其他物种
  • Diet ingredients  饮食成分

Medicated diets  药物饮食

Teklad medicated lab animal diets are manufactured either at a subsidiary plant or at our custom research diet facility. Contact customer service or your local Envigo account representative for pricing and availability of stocked diets. Contact a nutritionist to discuss customized versions of these or other medicated diets.

Medicated diets must be used as directed by a veterinarian.

Stocked medicated rodent diets
Primary Purpose Product Code Medication Concentration Base diet Packaging
Fur mite treatment TD.130755 Ivermectin 12 ppm 2018 25 lb bag- irradiated
Pinworm treatment TD.01432 Fenbendazole 150 ppm 2018S 25 lb bag- irradiated*
50 lb bag- autoclavable
Pneumocystis pneumonia
prevention
TD.06596 Uniprim® 275 ppm trimethoprim
1365 ppm sulfadiazine
2018 25 lb bag- irradiate

Harlan Teklad TD.120240 Doxycycline饲料 40 ppm Doxy Diet (2018, B)

Harlan Teklad TD.120240 Doxycycline饲料 40 ppm Doxy Diet (2018, B)

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Formula g/Kg
2018, Teklad Global 18% Protein Rodent Diet 999.704
Doxycycline Hyclate 0.046
Blue Food Color 0.25

Key Features

  • Standard Diet Base
  • 2018
  • Doxycycline
  • Color Coded Blue

Key Planning Information

  • Products are made fresh to order
  • Store product at 4°C or lower
  • Use within 6 months (applicable to most diets)
  • Box labeled with product name, manufacturing date, and lot number
  • Replace diet at minimum once per week  More frequent replacement may be advised
  • Lead time:    2 weeks non-irradiated     4 weeks irradiated

Footnote

Modification of TD.10483 to add blue coloring. Designed to add 40 mg doxycyline/kg diet using the Teklad 2018 Global Rodent Diet as the base. Doxycycline hyclate contains approximately 87% doxycycline.

Selected Nutrient Information1

  % by weight % kcal from
Protein 18.2 22.9
Carbohydrate2 48.0 60.5
Fat 5.8 16.6
Kcal/g 3.2  
  • Values are calculated from ingredient analysis or manufacturer data
  • Estimated digestible carbohydrate

Product Specific Information

  • 1/2″ Pellet or Powder (free flowing)
  • Minimum order 3 Kg
  • Irradiation available upon request

Options (Fees Will Apply)

  • Rush order (pending availability)
  • Irradiation (see Product Specific Information)
  • Vacuum packaging (1 and 2 Kg)

Harlan Teklad Medicated diets 药物饲料

Harlan Teklad Medicated diets 药物饲料

Harlan Teklad代理,Harlan Teklad一级代理,欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。

Teklad medicated lab animal diets are manufactured either at a subsidiary plant or at our custom research diet facility. Contact customer service or your local Envigo account representative for pricing and availability of stocked diets. Contact a nutritionist to discuss customized versions of these or other medicated diets.

特克拉德药物实验室动物饮食是在一个附属工厂或在我们的定制研究饮食设施生产。与客户服务部门或当地Envigo客户代表联系,了解库存饮食的定价和供应情况。联系营养师讨论这些或其他药物饮食的定制版本。

Medicated diets must be used as directed by a veterinarian.

Stocked medicated rodent diets
Primary Purpose Product Code Medication Concentration Base diet Packaging
Fur mite treatment TD.130755 Ivermectin 12 ppm 2018 25 lb bag- irradiated
Pinworm treatment TD.01432 Fenbendazole 150 ppm 2018S 25 lb bag- irradiated*
50 lb bag- autoclavable
Pneumocystis pneumonia
prevention
TD.06596 Uniprim® 275 ppm trimethoprim
1365 ppm sulfadiazine
2018 25 lb bag- irradiated*
COLLAPSE ALL TABS

  • Testing shows very little medication loss due to manufacturing
  • Recommended storage at or below 70 degrees fahrenheit with humidity at or below 65%
  • Durable cylindrical pellets are visually distinct from flattened oval or extruded pellets (see picture)
  • 2018 supports growth and reproduction
  • 2018 is closely related to other Global Rodent Diets, and shares some commonality with traditional rodent diets

The anthelmintic ivermectin is used for the treatment of fur mites. TD.130755 (Irradiated 2018, 12 ppm Ivermectin) is stocked in 25 lb bags. Contact customer service regarding availability of TD.130755.

The anthelmintic fenbendazole is used for treatment of pinworms. TD.01432 (2018S, 150 ppm fenbendazole) is stocked in 25 lb bags that are irradiated or in 50 lb bags that can be autoclaved (note autoclaving reduces fenbendazole concentration and is only recommended if using to treat mice). Contact customer service regarding availability ofTD.01432.

Uniprim® contains trimethoprim and sulfadiazine, used to prevent occurrences of Pneumocystis pneumonia in immunocompromised mice and rats. TD.06596 (Irradiated 2018, 4100 ppm Uniprim®) is stocked in 25 lb bags. Contact customer service regarding availability of TD.06596.

Custom diets with Ivermectin, Uniprim®, and Fenbendazole are available. Modifications include: different base diet, coloring with food dyes, and other dosing concentrations based on your unique requirements. Contact a nutritionist to discuss your needs.

Other medications and compounds such as doxycycline and tamoxifen may be added to diets at our custom research diet facility. Visit our custom research diets site or contact us

药物饮食必须按照兽医的指示使用。

含药啮齿动物饲料
主要目的 产品代码 药物治疗 浓度 基础饮食 包装
毛螨处理 TD.130755 伊维菌素 百万分之十二 2018 25磅包-辐照
粉螨治疗 TD.01432 芬苯达唑 百万分之150 2008 S 25磅包-辐照*
50磅包-高压釜
肺孢子虫p肺炎
预防
TD.06596 Uniprim® 275 ppm甲氧苄啶
1365 ppm磺胺嘧啶
2018 25磅包-辐照*
COLLAPSE ALL TABS

  • 测试显示制造过程中药物损失很小。
  • 建议贮存温度在华氏70度或以下,湿度在65%或以下
  • 耐用的圆柱形球团在视觉上有别于扁平的椭圆形或挤压球团(见图)
  • 2018支持生长和繁殖
  • 2018与其他全球啮齿动物饮食密切相关,并与传统的啮齿动物饮食有一些共同之处

这个驱虫药伊维菌素用于治疗毛皮螨。TD.130755(辐照2018年,12 ppm伊维菌素)储存在25磅袋。与客户服务部门联系,了解TD.130755.

本发明为驱虫药芬苯达唑。TD.01432(2018S,150 ppm芬苯达唑)储存在25磅经辐照的袋子中,或装在50磅可被压的袋子中(注意,高压灭菌可以降低芬苯达唑的浓度,只有当用于治疗小鼠时才推荐使用)。与客户服务部门联系,了解TD.01432.

Uniprim®含有甲氧苄啶和磺胺嘧啶,用于预防免疫受损小鼠和大鼠肺炎肺孢子虫肺炎的发生。TD.06596(2018年辐照,4100 ppm Uniprim)®)装在25磅重的袋子里。与客户服务部门联系,了解TD.06596.

伊维菌素定制饮食®,芬苯达唑是可行的。修改包括:不同的基础饮食,染色与食物染料,以及其他剂量的浓度,根据您的独特要求。联系营养师来讨论你的需求。

其他药物和化合物,如强力霉素和他莫昔芬可以添加到我们的定制研究饮食设施的饮食。访问我们的定制研究饮食网站或联系我们以获得更多信息。

Harlan Teklad 他莫昔芬动物饲料 Tamoxifen diets

Harlan Teklad 他莫昔芬动物饲料 Tamoxifen diets

Diets with tamoxifen activate CreER

Several references cite use of tamoxifen-containing diets for models with Cre under the control of a mutated estrogen receptor. Envigo Teklad diets makes a variety of tamoxifen-containing diets customized to meet your research needs. We also make a variety of doxycycline-containing diets for tet regulated systems. If you have any questions, don’t hesitate to consult a nutritionist.

Teklad stocks tamoxifen and tamoxifen citrate

Tamoxifen is added to the diet as a tamoxifen-sucrose mixture. Users are encouraged to use the stocked supply. However, Teklad will continue to work with customer prepared mixes. If you choose this option, please consult a nutritionist for additional information about preparing and sending the mixture.

Users are encouraged to select from the stocked options below supply readily available to ship within days.

Teklad offers diet with USP grade tamoxifen and tamoxifen citrate
Tamoxifen
mg per kg diet
Daily tamoxifen
mg per kg body weight1
Diet code
(Teklad supplied tamoxifen)
    Natural colored Red
250 40 TD.130855 TD.130856
500 80 TD.130857 TD.130858
400 citrate2 40 TD.130859 TD.1308603

1 Assumes 20-25 g body weight and three-four g intake
2 Tamoxifen citrate is 66% tamoxifen
3 Referred to as TAM400/CreER in Europe (TD.55125)

Please add 5-10 day lead time for irradiated diets; minimum 3 kg orders are required for stocked and customized items.

These diets all have tamoxifen premixed with ~five percent sucrose as a palatability enhancer; however, feed aversion may still occur. If intake is a problem, see below for advice.

Teklad Global 2016 — base diet in these examples — is only one of several minimal phytoestrogen diets Teklad produces. Consult a nutritionist about use of other base diets.

COLLAPSE ALL TABS

  • Minimum order quantity is three kg, sufficient for feeding ~20 mice for one month
  • Store diet refrigerated and plan to use within six months
  • Typical lead time is two weeks (four weeks if irradiated)
  • Irradiation (optional) minimal dose of 20 kGy (Must be requested at time of order)
  • To place an order: contact Teklad Customer Service at 800.483.5523 or initiate order online

Plan for:

  • Initial reduction in food intake and weight loss
  • Daily observation of animal tolerance — consult your IACUC for monitoring metrics
  • Intervene when necessary

If intake seems to be a problem:

  • Determine if a lower dose is effective for your model by conducting a tamoxifen dose feeding trial
  • Gradually acclimate mice by mixing tamoxifen-containing pellets with regular feed pellets
  • Wet the food, then place in a dish inside the cage (requires daily replacement)
  • Feed tamoxifen diet on weekdays, regular diet on weekends
  • Alternate weeks (two weeks on tamoxifen diet, one week off) for longer treatments
  • Tamoxifen is a selective estrogen receptor modulator (SERM) meaning it can repress actions of estrogen or have pro-estrogen effects
  • Usual dose for therapeutic effects in humans is 20 mg/day. Tamoxifen diets for rodents typically contain ~one to two mg/pellet
  • Accidental tamoxifen exposure can be minimized by using typical lab precautions of lab coat, gloves, and mask when handling the diet.
  • Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of tamoxifen containing diets.
  • Length of treatment varies from one to two weeks1,2,5,6,7,8 to one to two months3,4,8
  • Pure tamoxifen1,5,8 and tamoxifen citrate1,2,3,4,6,7 are both effective
  • Usual tamoxifen doses are ~40-80 mg per kg body weight per day
  • Typical inclusion for pure tamoxifen is 250 mg8 or 500 mg1,5 and for tamoxifen citrate is 400 mg per kg diet1,2,3,4,6,7
  • Initial weight loss of ten % is reported1,2,4,7,8, associated with reduced food intake2
  • Subsequent recovery of body weight after returning to regular diet may be compromised by gene inactivation2,7
  1. Andersson KB, Winer LH, Mork HK, Molkentin JD, Jaisser F. 2010. Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts. Transgenic Res 19:715-725.
  2. Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci USA 107:16320-16324.
  3. Kardakaris R, Gareus R, Xanthoulea S, Pasparakis M. 2011. Endothelial and macrophage-specific deficiency of P38alpha MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS One 6:e21055.
  4. Kiermayer C, Conrad M, Schneider M, Schmidt J, Brielmeier M. 2007. Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis 45:11-16.
  5. Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA. 2009. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res 105:12-15.
  6. Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, Mourkioti F. 2009. Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. PCirc Res 106:559-572.
  7. Miro-Murillo M, Elorza A, Soro-Arnaiz I, Albacete-Albacete L, Ordonez A, Balsa E, Vara-Vega A, Vazquez S, Fuertes E, Fernandez-Criado C, Landazuri MO, Aragones J. 2011. Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression. PLoS One 6:e22589.
  8. Welle S, Burgess K, Thornton CA, Tawil R. 2009. Relation between extent of myostatin depletion and muscle growth in mature mice. Am J Physiol Endocrinol Metab.Oct;297(4):E935-40.

Harlan 强力霉素饲料 Doxycycline diets

Harlan 强力霉素饲料 Doxycycline diets

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Doxycycline diets

Envigo Teklad diets makes a variety of doxycycline containing diets for your Tet regulated systems. TD.01306 with doxycycline hyclate added at 625 mg/kg to Teklad global 2018 rodent diet is stocked and can typically ship within 1 – 2 days (non-irradiated) or 1 – 2 weeks (irradiated). Diets are easily customizable. Custom specifications include: base diet, concentration of doxycycline, and food coloring. Contact us to discuss your needs if you don’t find a suitable option below.

EnvigoTeclad饮食使各种多西环素包含饮食为您的Tet调节系统。TD.01306以625毫克/千克的强力霉素添加到2018年全球啮齿动物饲料中,通常可在1至2天(未辐照)或1-2周(辐照)内装运。饮食很容易定制。定制规格包括:基础饮食,多西环素浓度和食用色素。联系我们如果你在下面找不到合适的选择的话,来讨论你的需求。

Formula examples with Teklad global 2018 base diet
Doxycycline hyclate1 USP (mg/kg diet) Natural color Alternatives with food coloring
mg per kg diet
46 TD.10483 TD.180327 Red
TD.120240 Blue
100 TD.04233 TD.130840 Blue
200 TD.00502 TD.180625 Red
TD.150431 Blue
TD.04104 Green
625 TD.01306
stocked2
TD.08541 Red
TD.120769 Blue
TD.09628 Green
1000 TD.05298 TD.06294 Red
TD.120658 Blue
2000 TD.05512 TD.140011 Red
TD.09633 Green
6000 TD.01533

1 Doxycycline hyclate is ~87% doxycycline
2 TD.01306 typically ships within 2 days non-irradiated or 2 weeks with irradiation

Considerations when choosing a base diet

    • Teklad Global Rodent Diets® like 2018 do not contain alfalfa and are thus ideal if your work requires an alfalfa-free diet for fluorescent imaging, If further imaging clarity is needed, we can make purified diets with doxycycline.
    • Teklad global 2018 (base diet in examples above) contains a moderate amount of soybean meal, a source of phytoestrogens. The table below includes several options of minimal phytoestrogen diets with the most common doxycycline concentration of 625 mg/kg diet. For other concentrations contact us. For additional phytoestrogen information, see our list of phytoestrogen references.
Examples of minimal phytoestrogen global rodent diets with doxycycline hyclate1 at 625 mg/kg diet
Base diet Natural color Alternatives with food coloring
mg per kg diet
2014 TD.00426 TD.07382 Red
TD.07573 Yellow
2016 TD.02503 TD.140263 Blue
TD.170364 Red
2019 TD.09651 TD.09761 Green
2020 TD.110720 TD.130141 Red

1 Doxycycline hyclate is ~87% doxycycline

Advantages of diet delivery of doxycycline

  • Typically the same doxycycline concentration can be used in diet as in water. Lower concentrations of doxycycline may be adequate with 625 mg/kg diet being the most common concentration.
  • Diet offers protection from light. Water may have to be given in dark-colored or foil-wrapped bottles
  • Diet is typically changed once per week. Water may need to be changed every few days
  • Diet delivery may also reduce risk of dehydration and preclude the need to give with sucrose (Cawthorne et. al. 2007)

Key planning information

  • Minimum order quantity is 3 kg, sufficient for feeding ~20 mice for one month
  • Store diet refrigerated and plan to use within six months
  • Typical lead time is two weeks (four weeks if irradiated)
    • TD.01306 typically ships within 2 days non-irradiated or 2 weeks with irradiation
  • Irradiation (20 – 50 kGy) is optional, and must be requested at time of order

Safe handling of doxycycline diets

  • Doxycycline is a tetracycline class antibiotic.
  • Usual dose for therapeutic effects in humans is 100-200 mg/day. Doxycycline diets for rodents typically contain ~2 mg/pellet.
  • Accidental doxycycline exposure can be minimized by using typical lab precautions of lab coat, gloves, and mask when handling the diet.
  • Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of doxycycline containing diets.

多西环素饮食给药的优势

  • 典型的多西环素浓度可以用于饮食和水。低浓度的多西环素可能足够,625毫克/千克的饮食是最常见的浓度。
  • 饮食能保护身体免受光线伤害。水可能必须用深色或铝箔包装的瓶子浇水。
  • 饮食通常每周改变一次。水可能需要每隔几天更换一次。
  • 饮食供应也可以减少脱水的风险,并避免需要给予蔗糖(考索恩等)。艾尔。(2007年)

关键规划信息

  • 最小订货量为3公斤,足以喂养20只小鼠一个月。
  • 储存冷冻饮食,并计划在六个月内使用。
  • 典型的准备时间为两周(如果经过辐照,则为四周)
    • TD.01306通常在未经辐照的2天内或在辐照的2周内装运。
  • 辐射(20-50 kGy)是可选的,必须按顺序要求。

多西环素饮食的安全处理

  • 强力霉素是四环素类抗生素。
  • 人体治疗效果的一般剂量为每天100至200毫克。用于啮齿动物的多西环素饮食通常含有~2毫克/粒。
  • 当处理饮食时,使用典型的实验室预防措施,如实验室外套、手套和口罩,可以将多西环素意外暴露量降到最低。
  • 您的化学安全部门应联系,以获得额外的机构特定的指导方针,以处理和处置多西环素的饮食。