Harlan TD.00158 维生素A缺乏饮食 Vitamin A Deficient Diet

货号：TD.00158

英文名称：Vitamin A Deficient Diet

Footnote
This modification of diet AIN-93G (TD 94045) omits vitamin A palmitate and
substitutes alcohol-extracted casein for regular casein. Diet should contain
less than 20 IU vitamin AVkg diet.

Selected Nutrient Information

Key Features
+ Purified Diet
+ Vitamin A
+ VFT Casein
+ AIN-93G Modification

Key Planning Information
+ Products are made fresh to order
+ Store product at 4°C or lower   将产品存放在4°C或更低的温度下

+Use within 6 months (applicable to most diets)
+ Box labeled with product name,
manufacturing date, and lot number
+ Replace diet at minimum once per week
More frequent replacement may be advised

+ Lead time:
2 weeks non-irradiated
4 weeks irradiated

Product Specific Information
1/2”Peilet of Powder (free flowing)  1/2”粉饼（自由流动）
+ Minimum order 3 Kg
+ Irradiation not advisea
Contact a nutntionist for recommendations

Harlan Teklad 动物饲料 Vitamin A Diet(25,000)成分表

Harlan Teklad动物饲料
Harlan代理–上海金畔生物科技有限公司
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。

Foothote

This modification of diet AIN-93G (TD.94045) replaces vitamin A palmitate with
tamin A acetate and increases the total concentration to approximately 25,000
/kg. Alcohol-extracted casein is substituted for regular casein.

Selected Nutrient Information

Values are calculated from ingredient analysis or manufacturer data

Key Features

+ Purifield   Diet
+Vitamin A
+AlN 93G Modification
+ Rodent

Key Planning Information

+ Product are made Fresh fo order
+ store product at 4° C or IoWer
+ Use within 6 months(appIicable to most diets)
+ Box Labeled with product name
manufaGturing date,and Iot number
+ Replace diet at nninimunη once per weekation

Harlan动物饲料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 成分表

Harlan Teklad动物饲料
Harlan代理–上海金畔生物科技有限公司
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。

啮齿动物饲料（2018，625强力霉素）

Footnote   Harlan动物饲料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 使用说明

This diet was designed to deliver a daily dose of 2-3 mg of doxycycline based on consumption of 4-5 g/d by a mouse. Doxycycline hyclate contains approximately 87% doxycycline.

这种饮食被设计为以小鼠每天4-5 g / d的消耗量提供2-3 mg强力霉素的日剂量。 盐酸多西环素含有约87％的多西环素。

Selected Nutrient Information

• Values are calculated from ingredient analysis or manufacturer data

• Estimated digestible carbohydrate

Key Features

• Standard Diet Base
• Doxycycline
• Gene Induction
• 2018

Key Planning Information

• Products are made fresh to order
• Store product at 4°C or lower
• Use within 6 months (applicable to most diets)
• Box labeled with product name, manufacturing date, and lot number
• Replace diet at minimum once per week

More frequent replacement may be advised

• Lead time:
• 2 weeks non-irradiated
• 4 weeks irradiated

Product Specific Information

• 1/2″ Pellet or Powder (free flowing)
• Minimum order 3 Kg
• Irradiation available upon request

Harlan Teklad Diet ingredients

Teklad diet, bedding and enrichment + Teklad laboratory animal diets + Custom research diets + Diet ingredients

You may want to prepare your own diet at your research site or facility, and if that is the case, you depend on the ingredients being of the highest quality. Envigo can provide you with many of the same ingredients used to produce our advanced Teklad custom research diets so you can develop your own formula. And as always, our nutritional experts are here to help you make the best decisions for your ingredients and ultimate formulation.

Our ingredients

We offer several ingredients for individual sale so that you can develop your own blends.

“VFT” casein

• “Vitamin-free” test casein (alcohol-extracted) is best suited for purified test diet formulas where fat or vitamin content needs to be precisely controlled
• The reduced levels of many vitamins in VFT casein make it the preferred protein source for many vitamin studies. Thus, the nickname “Vitamin-free” was given to the extracted casein many years ago

Vitamin mixes

• The common vitamin mixes shown below use sucrose or corn starch as a carrier
• Customized vitamin mixes may use cellulose if a non-nutritive carrier is necessary
• Vitamin mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of your laboratory animal
• For those preparing their own diets, vitamin premixes are an efficient way to add vitamins to a diet
• Vitamin mixes should be stored at 4 degrees celsius or lower upon receipt. Storage at –20 degrees celsius is recommended if the mix will be used beyond 1 month
• Minimum order is 500 g for both stock and custom vitamin mixes
• Our available vitamin mixes are commonly used in diets, and are available from stock
• Vitamin mixes are shipped within a few days of order

Our Formula examples

• CA.40060 Teklad vitamin mix
• CA.40077 AIN-76A vitamin mix
• TD.94047 AIN-93 vitamin mix

Mineral mixes

• The common mineral mixes shown below as examples use sucrose as a carrier
• Customized mineral mixes could use cellulose or no carrier if a non-nutritive carrier is necessary
• Our mineral mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of the animal
• For those preparing their own diets, mineral premixes are an efficient way to add minerals to a diet
• Mineral mixes should be stored in a dry cool environment and used within a year of receipt. The minimum order is 500 g for both stock and custom mineral mixes
• These mineral mixes are commonly used in diets, and are available from stock
• Our mineral mixes are shipped within a few days of order

Formula examples:

• CA.170915 AIN-76 mineral mix
• TD.94046 AIN-93G mineral mix
• TD.94049 AIN-93M mineral mix

Other mixes (may or may not be available from stock):

• TD.83171 Vitamin mix without A, D, E, choline
• TD.81062 Iron deficient mineral mix based on AIN-76A
• TD.79055 Calcium and phosphorus deficient mineral mixed based on AIN-76
• TD.98057 Calcium and phosphorus deficient mineral mixed based on AIN-93
• CA.170760 Rogers-Harper mineral mix

你可能想要在你的研究地点或设施准备你自己的饮食，如果是这样的话，你取决于成分是最高的质量。Envigo可以为您提供许多相同的成分，用于生产我们先进的特克拉德定制研究饮食，以便您可以开发自己的配方。和往常一样，我们的营养专家在这里帮助您为您的配料和最终配方做出佳决定。

我们的配料

我们提供几个配料供个人销售，以便您可以开发自己的混合。

“VFT”酪蛋白

• “无维生素”测试酪蛋白(酒精提取)最适合于那些需要精确控制脂肪或维生素含量的纯正试验饮食配方。
• VFT酪蛋白中许多维生素含量的降低使得它成为许多维生素研究的首选蛋白质来源。因此，“无维生素”的绰号是在许多年前给提取出来的酪蛋白起的。

维生素混合物

• 以下常见的维生素混合物使用蔗糖或玉米淀粉作为载体。
• 定制的维生素混合物可能使用纤维素，如果非营养载体是必要的。
• 维生素混合物的制定考虑到了饮食中的包容率。多用或少用会损害你的实验动物的健康。
• 对于那些自己准备饮食的人来说，维生素预混剂是向饮食中添加维生素的一种有效方法。
• 维生素混合物应储存在4摄氏度或更低的接收。如果使用时间超过1个月，建议使用摄氏-20度。
• 库存和定制维生素混合物的最低订购量为500克。
• 我们可用的维生素混合物通常用于饮食，并可从库存中获得。
• 维生素混合物在订购后几天内发货。

我们的公式示例

• CA.40060 特克拉德维生素混合物
• CA.40077 AIN-76A维生素混合物
• TD.94047 AIN-93维生素混合物

矿物混合物

• 下面所示的常见矿物混合物是以蔗糖为载体的。
• 如果需要非营养的载体，定制的矿物混合物可以使用纤维素，也可以不使用载体。
• 我们的矿物质混合物是根据饮食包容率来制定的。多用或少用会损害动物的健康。
• 对于那些自己准备饮食的人来说，矿物预混料是向饮食中添加矿物质的有效方法。
• 矿物混合物应存放在干燥、凉爽的环境中，并在收到后一年内使用。库存和自定义矿物混合物的最低订购量为500克。
• 这些矿物混合物通常用于饮食，并可从库存中获得。
• 我们的矿物混合物在订货后几天内装运。

公式示例：

• CA.170915 AIN-76矿物混合物
• TD.94046 AIN-93g矿物混合物
• TD.94049 AIN-9300万矿物混合物

其他混合材料(可能从库存中获得，也可能无法从库存中获得)：

• TD.83171不含A，D，E，胆碱的维生素混合物
• TD.81062基于AIN-76A的缺铁矿物配料
• TD.79055 AIN-76混合钙磷缺乏矿物
• TD.98057AIN-93混合钙磷缺乏矿物
• CA.170760 罗杰斯-哈珀矿物混合物

Harlan Teklad 2016 global 16% protein rodent diets

Product Features

• Designed to support growth and maintenance
• Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of phytoestrogen found in lab animal diets
• Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
• Exclusion of alfalfa reduces chlorophyll, greatly improving fluorescent optical imagingclarity
• Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

Teklad Global 16% Protein Rodent Diet

Product Description- 2016 is a fixed formula, non-autoclavable diet
manufactured with high quality ingredients and designed to support growth
and maintenance. 2016 does not contain alfalfa or soybean meal, thus
minimizing the occurrence of natural phytoestrogens. Typical isoflavone
concentrations (daidzein + genistein aglycone equivalents) range from nondetectable
to 20 mg/kg. Exclusion of alfalfa reduces chlorophyll, improving
optical imaging clarity. Absence of animal protein and fish meal minimizes
the presence of nitrosamines. Also available certified (2016C) and
irradiated (2916). For autoclavable diet, refer to 2016S (Sterilizable).

Macronutrients

Teklad Diets are designed and manufactured for research purposes only.

Ingredients (in descending order of inclusion)- Ground wheat, ground corn, wheat middlings, corn gluten meal, calcium carbonate, dicalcium phosphate, soybean oil, brewers dried yeast, iodized salt, L-lysine, DL-methionine, choline chloride, magnesium oxide, vitamin E acetate, menadione sodium bisulfite complex (source of vitamin K activity), manganous oxide, ferrous sulfate, zinc oxide, niacin, calcium pantothenate, copper sulfate, pyridoxine hydrochloride, riboflavin, thiamin mononitrate, vitamin A acetate, calcium iodate, vitamin B₁₂ supplement, folic acid, biotin, vitamin D₃ supplement,

cobalt carbonate.

Vitamins

• Ether extract is used to measure fat in pelleted diets, while an acid hydrolysis method is required to recover fat in extruded diets. Compared to ether extract, the fat value for acid hydrolysis will be approximately 1% point higher.

• Carbohydrate (available) is calculated by subtracting neutral detergent fiber from total carbohydrates.

• Neutral detergent fiber is an estimate of insoluble fiber, including cellulose, hemicellulose, and lignin. Crude fiber methodology underestimates total fiber.

• Energy density is a calculated estimate of metabolizable energybased on the Atwater factors assigning 4 kcal/g to protein, 9 kcal/g to fat, and 4 kcal/g to available carbohydrate.

• Indicates added amount but does not account for contribution from other ingredients.

• 1 IU vitamin A = 0.3 µg retinol

• 1 IU vitamin D = 25 ng cholecalciferol

For nutrients not listed, insufficient data is available to quantify.

Nutrient data represent the best information available, calculated from published values and direct analytical testing of raw materials and finished product. Nutrient values may vary due to the natural variations in the ingredients, analysis, and effects of processing.

Harlan 啮齿类饲料 Rodent diets

As a researcher, you want to have as much control as possible over what goes into your study animals. At Envigo, we understand that. That is why we developed Teklad Global Rodent Diets®.

Teklad Global Rodent Diets® are a special integrated range of vegetarian laboratory rodent diets developed to be nutritionally complete for various life stages from breeding through long-term maintenance. Global rodent laboratory diets contain levels of protein, energy, vitamins and minerals that are more appropriate to the needs of modern biomedical research studies.

Furthermore, in global rodent diets particular attention has been placed on avoiding, as far as practical, ingredients that are reported to have adverse confounding effects on experimental results. This has resulted in a range of Teklad rodent laboratory diets that contain:

No fish meal

No meat meals or meat by-products

No alfalfa meal

No soybean meal or reduced levels

No animal fat

By excluding animal by-products, the presence of nitrosamines (a potential carcinogen) is avoided. Exclusion of alfalfa meal reduces chlorophyll, improving optical imaging clarity. Reduction or removal of soybean meal, together with elimination of alfalfa meal, minimizes levels of naturally-occurring phytoestrogens. Phytoestrogens interact with endogenous estrogens and potentially can affect studies in many research areas. Read more about this in these pieces:

Dietary phytoestrogens, a source of research variation
Ask a Nutritionist Series: Impact of phytoestrogens on research, Volume 1

Phytoestrogens limit translation of preclinical results to clinical outcomes
Ask a Nutritionist Series: Impact of phytoestrogens on research, Volume 2

Harlan TD.88137 高酯饲料Adjusted calories diet (42% from fat)说明书

Harlan Teklad代理，欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。

A staple of atherosclerosis research

More than 25 years ago, our nutritionists collaborated with researchers at Rockefeller University to develop a diet with features of a ‘Western Diet’ to characterize and enhance atherosclerosis development in their newly generated Apoe deficient mouse model.

With over 200 unique users worldwide, TD.88137 continues to be fed to genetically modified cardiovascular models to accelerate and enhance hypercholesterolemia and plaque formation.

Selected nutrient information1

• Values are calculated from ingredient analysis or manufacturer data.
• 15% added, 0.05% from fat source.

Critical dietary features of TD.88137 related to atherosclerosis development include:

++Cholesterol (0.2% total cholesterol)

++Total fat (21% by weight; 42% kcal from fat)

++High in saturated fatty acids

(>60% of total fatty acids)

++High sucrose (34% by weight)

Typical fatty acid profile of TD.88137

• n = 21, analysis conducted by two independent laboratories.
• Unidentified fatty acids and those contributing on average less than 0.5% of total fatty acids.
• Includes trans isomers elaidic and vaccenic acid and unidentified cis isomers.
• Includes trans isomers.

Key points from the literature

TD.88137 has been used to accelerate atherosclerosis development in Apoe and Ldlr deficient models:

++In Apoe deficient mice, plasma cholesterol triples to >1500 mg/dL within three weeks (1, 2). Foam cell and lesion development occurs within 6-10 weeks (2-4). Fibrous plaque formation is observed at 15 weeks with the development of fibrous caps after 20 weeks (2).

++Ldlr deficient mice fed for two weeks increase plasma cholesterol to >800 mg/dL and triglyceride to >300 mg/dL (5). After six weeks of feeding, hyperglycemia, hyperinsulinemia and dyslipidemia develop with small foam cell lesions in the aortic arch (6, 7).

For further information about TD.88137, or if you are interested in learning more about other atherogenic or high fat diets contact us at

With over 420 citations, uses of TD.88137 continue to evolve and include atherosclerosis, obesity, non-alcoholic steatohepatitis (NASH), osteoporosis, hypertension and metabolic syndrome. Contact us for a more extensive reference list.

Control diet options for TD.88137

Natural ingredient diets

++Also referred to as standard diets or chow

++Diets differ in the source and level of nutrients as well as the presence of non-nutritive factors (such as phytates or phytoestrogens) compared to TD.88137

++Limits inferences to differences in dietary pattern versus a specific dietary component

Ingredient matched, low fat diets

++Controls for the type of ingredients, non-nutritive components and the source and level of specific nutrients

++Suggested ingredient matched, low fat dietary controls for TD.88137 listed below; data sheets can be found on our website at

Suggested ingredient matched, low fat controls

Additional controls are available. Contact a nutritionist at

Key planning information:

• Store diet refrigerated and plan to use within six months. Diet should be replaced at minimum once per week when fed on cage tops.
• Diets available as a soft ½” pellet or as a crumbly powder.
• Three kg minimum order quantity. For planning purposes, estimates for diet uses (including feed intake and diet waste) are 5 g of diet per mouse and 30 g of diet per rat per day.
• Two-day lead time for orders less than 10 kg. Two-week lead time for larger quantity orders.
• Lead time for irradiation adds two weeks for any quantity of diet and must be requested at the time you place your order. Changes in texture and browning may occur with irradiation.
• Shipping can affect pellet quality. Vacuum packaging can offer protection of the pellets during shipping. Two-day shipping is recommended during warmer months.

Contact us to place an order,

References

1. Plump, A.S., et al.,Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell, 1992. 71(2): p. 343-53.
2. Nakashima, Y., et al.,Apoe-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb, 1994. 14(1): p. 133-40.
3. Febbraio, M., et al.,Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice.

J Clin Invest, 2000. 105(8): p. 1049-56.

4. Nakashima, Y., et al.,Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the Apoe-deficient mouse. Arterioscler Thromb

Vasc Biol, 1998. 18(5): p. 842-51.

5. Towler, D.A., et al.,Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice.

J Biol Chem, 1998. 273(46): p. 30427-34.

6. Tsuchiya, K., et al.,FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab, 2012. 15(3): p. 372-81.
7. Huszar, D., et al.,Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler Thromb Vasc Biol, 2000. 20(4): p. 1068-73.
8. Yang, B., et al.,Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats. Biochem Biophys Res Commun, 2006. 341(1): p. 209-17.
9. Schafer, K., et al.,Leptin promotes vascular remodeling and neointimal growth in mice. Arterioscler Thromb Vasc Biol, 2004. 24(1): p. 112-7.
10. Lijnen, H.R., et al.,Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol, 2003. 23(1): p. 78-84.
11. Maquoi, E., et al.,Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes, 2002. 51(4): p. 1093-101.
12. VanSaun MN, et al. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol 175:355-64.
13. Dixon LJ, et al. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One 8:e56100.