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Harlan Teklad TD.08485 Low Fat Control Diet低脂饲料

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Harlan Teklad TD.08485 Low Fat Control Diet低脂饲料

Harlan Teklad代理，Harlan 饲料代理，欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。

Control diets can be designed in several ways, depending on what features the researcher wants to modify relative to the high-fat diet. These are just a few examples.

Commonly-used diet-induced obesity (DIO) Teklad rodent diets with 40-45% of calories from fat

Formula g/Kg
Casein 195
DL-Methionine 3
Sucrose 120
Corn Starch 432.99
Maltodextrin 100
Anhydrous Milkfat 37.2
Soybean Oil 12.8
Cellulose 50
Mineral Mix, AIN-76 (170915) 35
Calcium Carbonate 4
Vitamin Mix, Teklad (40060) 10
Ethoxyquin, antioxidant 0.01

Footnote

This is modified from TD.88137 to reduce fat, reduce sucrose, and remove cholesterol.

elected Nutrient Information1

 

% by weight % kcal from
Protein 17.3 19.1
Carbohydrate 61.3 67.9
Fat 5.2 13.0
Kcal/g 3.6
  • Values are calculated from ingredient analysis or manufacturer data

Key Features

  • Purified Diet
  • Modification of TD.88137
  • Low Fat & No Added Cholesterol
  • Reduced Sucrose

Key Planning Information

  • Products are made fresh to order
  • Store product at 4°C or lower
  • Use within 6 months (applicable to most diets)
  • Box labeled with product name, manufacturing date, and lot number
  • Replace diet at minimum once per week

More frequent replacement may be advised

  • Lead time:
  • 2 weeks non-irradiated
  • 4 weeks irradiated

 

Harlan TD.00158 维生素A缺乏饮食 Vitamin A Deficient Diet 使用说明

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Harlan TD.00158 维生素A缺乏饮食 Vitamin A Deficient Diet

货号：TD.00158

英文名称：Vitamin A Deficient Diet

Formula g/Kg
Casein,”iamin-Freet”Test 200
L-Cystine 3
Com Starch 397.486
Maltodextrin 132
Sucrose 109.755
Soybean Oil 70
Cellulose 50
Mineral Mix, AIN-93G-MX (94046) 35
Choline Bitartrate 2.5
TBHQ, antioxidant 0.014
Niacin 0.03
Calcium Pantothenate 0.016
Pyridoxine HCI 0.007
Thiamin (81%) 0.006
Riboflavin 0.006
Folic Acid 0.002
Biotin 0.0002
Vitamin B.2 (0.1% in mannitol) 0.025
Vitamin E DL-alpha tocooheryl acetate (500 IU/g) 0.15
Vitamin D3 cholecalciferol (500,000 lU/g) 0.002
Vitamin K1. phyloquinone 0.0008

Footnote
This modification of diet AIN-93G (TD 94045) omits vitamin A palmitate and
substitutes alcohol-extracted casein for regular casein. Diet should contain
less than 20 IU vitamin AVkg diet.

Selected Nutrient Information

% by weight % kcal from
Protein 18.3 19.4
Carbohydrate 60.1 63.8
Fat 7 16.7
Kcalg 3.8

Key Features
+ Purified Diet
+ Vitamin A
+ VFT Casein
+ AIN-93G Modification

Key Planning Information
+ Products are made fresh to order
+ Store product at 4°C or lower   将产品存放在4°C或更低的温度下

+Use within 6 months (applicable to most diets)
+ Box labeled with product name,
manufacturing date, and lot number
+ Replace diet at minimum once per week
More frequent replacement may be advised

+ Lead time:
2 weeks non-irradiated
4 weeks irradiated

Product Specific Information
1/2”Peilet of Powder (free flowing)  1/2”粉饼（自由流动）
+ Minimum order 3 Kg
+ Irradiation not advisea
Contact a nutntionist for recommendations

Harlan Teklad 动物饲料 Vitamin A Diet(25,000)成分表

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Harlan Teklad 动物饲料 Vitamin A Diet(25,000)成分表

Harlan Teklad动物饲料
Harlan代理–上海金畔生物科技有限公司
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。

Formula g/Kg
Casein, “Vitamin-Free”Test 200
L-Cystine 3
Com Starch 397.486
Maltodextrin 132
Sucrose 109.705
Soybean Oil 70
Cellulose 50
Mineral Mix, AIN-93G-MX (94046) 35
Choline Bitartrate 2.5
TBHQ, antioxidant 0.014
Niacin 0.03
Calcium Pantothenate 0.016
Pyridoxine HCI 0.007
Thiamin (81%) 0.006
Riboflavin 0.006
Folic Acid 0.002
Biotin 0.0002
Vitamin B12 (0.1% in manitol) 0.025
Vitamin E DL alpha tocopheryl acetate (500 IU/g) 0.15
Vitamin D3. cholecalciferol (500,000 IU/g) 0.002
Vitamin K1, phylloquinone 0.0008
Vitamin A Acetate (500,000 IU/g) 0.05

Foothote

This modification of diet AIN-93G (TD.94045) replaces vitamin A palmitate with
tamin A acetate and increases the total concentration to approximately 25,000
/kg. Alcohol-extracted casein is substituted for regular casein.

Selected Nutrient Information

% by weight % kcal from
Protein 18.3 19.4
Carbohydrate 60.1 63.8
Fat 7 16.7
Kcal/g 3.8

Values are calculated from ingredient analysis or manufacturer data

Key Features

+ Purifield   Diet
+Vitamin A
+AlN 93G Modification
+ Rodent

Key Planning Information

+ Product are made Fresh fo order
+ store product at 4° C or IoWer
+ Use within 6 months(appIicable to most diets)
+ Box Labeled with product name
manufaGturing date,and Iot number
+ Replace diet at nninimunη once per weekation

Harlan动物饲料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 成分表

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Harlan动物饲料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 成分表

Harlan Teklad动物饲料
Harlan代理–上海金畔生物科技有限公司
欢迎新老客户访问Harlan官网或者咨询中国代理商上海金畔生物获取更多详细资料。

啮齿动物饲料（2018，625强力霉素）

Formula g/Kg
2018, Teklad Global 18% Protein Rodent Diet 999.375
Doxycycline Hyclate 0.625

Footnote   Harlan动物饲料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 使用说明

This diet was designed to deliver a daily dose of 2-3 mg of doxycycline based on consumption of 4-5 g/d by a mouse. Doxycycline hyclate contains approximately 87% doxycycline.

这种饮食被设计为以小鼠每天4-5 g / d的消耗量提供2-3 mg强力霉素的日剂量。 盐酸多西环素含有约87％的多西环素。

Selected Nutrient Information

  % by weight % kcal from
Protein 18.2 22.9
Carbohydrate2 48.0 60.5
Fat 5.8 16.6
Kcal/g 3.2  
  • Values are calculated from ingredient analysis or manufacturer data
  • Estimated digestible carbohydrate

Key Features

  • Standard Diet Base
  • Doxycycline
  • Gene Induction
  • 2018

Key Planning Information

  • Products are made fresh to order
  • Store product at 4°C or lower
  • Use within 6 months (applicable to most diets)
  • Box labeled with product name, manufacturing date, and lot number
  • Replace diet at minimum once per week

More frequent replacement may be advised

  • Lead time:
  • 2 weeks non-irradiated
  • 4 weeks irradiated

Product Specific Information

  • 1/2″ Pellet or Powder (free flowing)
  • Minimum order 3 Kg
  • Irradiation available upon request

Harlan Teklad Diet ingredients

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Harlan Teklad Diet ingredients

Teklad diet, bedding and enrichment + Teklad laboratory animal diets + Custom research diets + Diet ingredients

You may want to prepare your own diet at your research site or facility, and if that is the case, you depend on the ingredients being of the highest quality. Envigo can provide you with many of the same ingredients used to produce our advanced Teklad custom research diets so you can develop your own formula. And as always, our nutritional experts are here to help you make the best decisions for your ingredients and ultimate formulation.

Our ingredients

We offer several ingredients for individual sale so that you can develop your own blends.

“VFT” casein

  • “Vitamin-free” test casein (alcohol-extracted) is best suited for purified test diet formulas where fat or vitamin content needs to be precisely controlled
  • The reduced levels of many vitamins in VFT casein make it the preferred protein source for many vitamin studies. Thus, the nickname “Vitamin-free” was given to the extracted casein many years ago

Vitamin mixes

  • The common vitamin mixes shown below use sucrose or corn starch as a carrier
  • Customized vitamin mixes may use cellulose if a non-nutritive carrier is necessary
  • Vitamin mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of your laboratory animal
  • For those preparing their own diets, vitamin premixes are an efficient way to add vitamins to a diet
  • Vitamin mixes should be stored at 4 degrees celsius or lower upon receipt. Storage at –20 degrees celsius is recommended if the mix will be used beyond 1 month
  • Minimum order is 500 g for both stock and custom vitamin mixes
  • Our available vitamin mixes are commonly used in diets, and are available from stock
  • Vitamin mixes are shipped within a few days of order

Our Formula examples

  • CA.40060 Teklad vitamin mix
  • CA.40077 AIN-76A vitamin mix
  • TD.94047 AIN-93 vitamin mix

Mineral mixes

  • The common mineral mixes shown below as examples use sucrose as a carrier
  • Customized mineral mixes could use cellulose or no carrier if a non-nutritive carrier is necessary
  • Our mineral mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of the animal
  • For those preparing their own diets, mineral premixes are an efficient way to add minerals to a diet
  • Mineral mixes should be stored in a dry cool environment and used within a year of receipt. The minimum order is 500 g for both stock and custom mineral mixes
  • These mineral mixes are commonly used in diets, and are available from stock
  • Our mineral mixes are shipped within a few days of order

Formula examples:

  • CA.170915 AIN-76 mineral mix
  • TD.94046 AIN-93G mineral mix
  • TD.94049 AIN-93M mineral mix

Other mixes (may or may not be available from stock):

  • TD.83171 Vitamin mix without A, D, E, choline
  • TD.81062 Iron deficient mineral mix based on AIN-76A
  • TD.79055 Calcium and phosphorus deficient mineral mixed based on AIN-76
  • TD.98057 Calcium and phosphorus deficient mineral mixed based on AIN-93
  • CA.170760 Rogers-Harper mineral mix

你可能想要在你的研究地点或设施准备你自己的饮食，如果是这样的话，你取决于成分是最高的质量。Envigo可以为您提供许多相同的成分，用于生产我们先进的特克拉德定制研究饮食，以便您可以开发自己的配方。和往常一样，我们的营养专家在这里帮助您为您的配料和最终配方做出佳决定。

我们的配料

我们提供几个配料供个人销售，以便您可以开发自己的混合。

“VFT”酪蛋白

  • “无维生素”测试酪蛋白(酒精提取)最适合于那些需要精确控制脂肪或维生素含量的纯正试验饮食配方。
  • VFT酪蛋白中许多维生素含量的降低使得它成为许多维生素研究的首选蛋白质来源。因此，“无维生素”的绰号是在许多年前给提取出来的酪蛋白起的。

维生素混合物

  • 以下常见的维生素混合物使用蔗糖或玉米淀粉作为载体。
  • 定制的维生素混合物可能使用纤维素，如果非营养载体是必要的。
  • 维生素混合物的制定考虑到了饮食中的包容率。多用或少用会损害你的实验动物的健康。
  • 对于那些自己准备饮食的人来说，维生素预混剂是向饮食中添加维生素的一种有效方法。
  • 维生素混合物应储存在4摄氏度或更低的接收。如果使用时间超过1个月，建议使用摄氏-20度。
  • 库存和定制维生素混合物的最低订购量为500克。
  • 我们可用的维生素混合物通常用于饮食，并可从库存中获得。
  • 维生素混合物在订购后几天内发货。

我们的公式示例

  • CA.40060 特克拉德维生素混合物
  • CA.40077 AIN-76A维生素混合物
  • TD.94047 AIN-93维生素混合物

矿物混合物

  • 下面所示的常见矿物混合物是以蔗糖为载体的。
  • 如果需要非营养的载体，定制的矿物混合物可以使用纤维素，也可以不使用载体。
  • 我们的矿物质混合物是根据饮食包容率来制定的。多用或少用会损害动物的健康。
  • 对于那些自己准备饮食的人来说，矿物预混料是向饮食中添加矿物质的有效方法。
  • 矿物混合物应存放在干燥、凉爽的环境中，并在收到后一年内使用。库存和自定义矿物混合物的最低订购量为500克。
  • 这些矿物混合物通常用于饮食，并可从库存中获得。
  • 我们的矿物混合物在订货后几天内装运。

公式示例：

  • CA.170915 AIN-76矿物混合物
  • TD.94046 AIN-93g矿物混合物
  • TD.94049 AIN-9300万矿物混合物

其他混合材料(可能从库存中获得，也可能无法从库存中获得)：

  • TD.83171不含A，D，E，胆碱的维生素混合物
  • TD.81062基于AIN-76A的缺铁矿物配料
  • TD.79055 AIN-76混合钙磷缺乏矿物
  • TD.98057AIN-93混合钙磷缺乏矿物
  • CA.170760 罗杰斯-哈珀矿物混合物

Harlan TD.88137 高酯饲料Adjusted calories diet (42% from fat)说明书

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Harlan TD.88137 高酯饲料Adjusted calories diet (42% from fat)说明书

Harlan Teklad代理，欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。

A staple of atherosclerosis research

More than 25 years ago, our nutritionists collaborated with researchers at Rockefeller University to develop a diet with features of a ‘Western Diet’ to characterize and enhance atherosclerosis development in their newly generated Apoe deficient mouse model.

With over 200 unique users worldwide, TD.88137 continues to be fed to genetically modified cardiovascular models to accelerate and enhance hypercholesterolemia and plaque formation.

Formula g/Kg
Casein 195.0
DL-Methionine 3.0
Sucrose 341.46
Corn Starch 150.0
Andydrous Milkfat 210.0
Cholesterol 1.5
Cellulose 50.0
Mineral Mix, AIN-76 (170915) 35.0
Calcium Carbonate 4.0
Vitamin Mix, Teklad (40060) 10.0
Ethoxyquin 0.04

Selected nutrient information1

% By weight % kcal from
Protein 17.3 15.2
Carbohydrate 48.5 42.7
Fat 21.2 42.0
kcal/g 4.5
Cholesterol2 0.2%
  • Values are calculated from ingredient analysis or manufacturer data.
  • 15% added, 0.05% from fat source.

Critical dietary features of TD.88137 related to atherosclerosis development include:

++Cholesterol (0.2% total cholesterol)

++Total fat (21% by weight; 42% kcal from fat)

++High in saturated fatty acids

(>60% of total fatty acids)

++High sucrose (34% by weight)

Typical fatty acid profile of TD.88137

Typical fatty acid analysis, Mean SD
% of diet1
Total 20.7 1.5
Saturated fat 12.8 0.8
Monounsaturated fat 5.6 0.5
Polyunsaturated fat 1.0 0.2
Unknown2 1.3 0.3
Typical fatty acid profile, Mean SD
% of total fatty acids1
Saturated fat 61.8 2.0
Monounsaturated fat 27.3 2.1
Polyunsaturated fat 4.7 0.8
4:0 2.1 1.1
6:0 1.5 0.7
8:0 1.1 0.3
10:0 2.6 0.5
12:0 3.3 0.5
14:0 10.6 0.9
16:0 28.9 1.3
16:1 1.5 0.2
18:0 12.5 0.8
18:1 (Oleic) 20.9 2.6
18:1 Isomers3 4.0 1.2
18:2 (Linoleic) 2.3 1.0
18:2 Isomers4 1.3 0.5
18:3 (Linolenic) 0.7 0.2
  • n = 21, analysis conducted by two independent laboratories.
  • Unidentified fatty acids and those contributing on average less than 0.5% of total fatty acids.
  • Includes trans isomers elaidic and vaccenic acid and unidentified cis isomers.
  • Includes trans isomers.

Key points from the literature

TD.88137 has been used to accelerate atherosclerosis development in Apoe and Ldlr deficient models:

++In Apoe deficient mice, plasma cholesterol triples to >1500 mg/dL within three weeks (1, 2). Foam cell and lesion development occurs within 6-10 weeks (2-4). Fibrous plaque formation is observed at 15 weeks with the development of fibrous caps after 20 weeks (2).

++Ldlr deficient mice fed for two weeks increase plasma cholesterol to >800 mg/dL and triglyceride to >300 mg/dL (5). After six weeks of feeding, hyperglycemia, hyperinsulinemia and dyslipidemia develop with small foam cell lesions in the aortic arch (6, 7).

For further information about TD.88137, or if you are interested in learning more about other atherogenic or high fat diets contact us at

With over 420 citations, uses of TD.88137 continue to evolve and include atherosclerosis, obesity, non-alcoholic steatohepatitis (NASH), osteoporosis, hypertension and metabolic syndrome. Contact us for a more extensive reference list.

Control diet options for TD.88137

Natural ingredient diets

++Also referred to as standard diets or chow

++Diets differ in the source and level of nutrients as well as the presence of non-nutritive factors (such as phytates or phytoestrogens) compared to TD.88137

++Limits inferences to differences in dietary pattern versus a specific dietary component

Ingredient matched, low fat diets

++Controls for the type of ingredients, non-nutritive components and the source and level of specific nutrients

++Suggested ingredient matched, low fat dietary controls for TD.88137 listed below; data sheets can be found on our website at

Suggested ingredient matched, low fat controls

Diet kcal/g Fat, % by % kcal Fat sources, Sucrose, %
weight from fat % by weight by weight
3.7% milk fat,
TD.05230 3.7 5.2 12.6 1.3% soybean 34.1
oil
3.7% milk fat,
TD.08485 3.6 5.2 13.0 1.3% soybean 12.0
oil

Additional controls are available. Contact a nutritionist at

Key planning information:

  • Store diet refrigerated and plan to use within six months. Diet should be replaced at minimum once per week when fed on cage tops.
  • Diets available as a soft ½” pellet or as a crumbly powder.
  • Three kg minimum order quantity. For planning purposes, estimates for diet uses (including feed intake and diet waste) are 5 g of diet per mouse and 30 g of diet per rat per day.
  • Two-day lead time for orders less than 10 kg. Two-week lead time for larger quantity orders.
  • Lead time for irradiation adds two weeks for any quantity of diet and must be requested at the time you place your order. Changes in texture and browning may occur with irradiation.
  • Shipping can affect pellet quality. Vacuum packaging can offer protection of the pellets during shipping. Two-day shipping is recommended during warmer months.

Contact us to place an order,

References

  1. Plump, A.S., et al.,Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell, 1992. 71(2): p. 343-53.
  2. Nakashima, Y., et al.,Apoe-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb, 1994. 14(1): p. 133-40.
  3. Febbraio, M., et al.,Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice.

J Clin Invest, 2000. 105(8): p. 1049-56.

  1. Nakashima, Y., et al.,Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the Apoe-deficient mouse. Arterioscler Thromb

Vasc Biol, 1998. 18(5): p. 842-51.

  1. Towler, D.A., et al.,Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice.

J Biol Chem, 1998. 273(46): p. 30427-34.

  1. Tsuchiya, K., et al.,FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab, 2012. 15(3): p. 372-81.
  2. Huszar, D., et al.,Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler Thromb Vasc Biol, 2000. 20(4): p. 1068-73.
  3. Yang, B., et al.,Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats. Biochem Biophys Res Commun, 2006. 341(1): p. 209-17.
  4. Schafer, K., et al.,Leptin promotes vascular remodeling and neointimal growth in mice. Arterioscler Thromb Vasc Biol, 2004. 24(1): p. 112-7.
  5. Lijnen, H.R., et al.,Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol, 2003. 23(1): p. 78-84.
  6. Maquoi, E., et al.,Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes, 2002. 51(4): p. 1093-101.
  7. VanSaun MN, et al. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol 175:355-64.
  8. Dixon LJ, et al. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One 8:e56100.

Harlan Teklad动物饲料分类

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Harlan Teklad动物饲料分类

Harlan Teklad代理，欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。

Standard natural ingredient diets  标准天然成分饮食

  • Rodent diets  啮齿类食物
  • Dog diets  狗粮
  • Rabbit diets   兔饲料
  • Guinea pig diets    豚鼠日粮
  • Primate diets  灵长类饮食
  • Swine diets  猪日粮
  • Other diets

Custom research diets  定制研究饮食

  • Ordering and services  订购和服务
  • NAFLD and NASH    NAFLD和NASH
  • AIN diet formulas   AIN饮食配方
  • Atherogenic    动脉粥样硬化

Atherogenic

Diet can be a useful tool to induce or accelerate atherosclerosis in laboratory animal models. Key dietary features used to induce atherosclerosis in rodents vary depending on the research model, desired endpoint, and length of feeding. While formulations of atherogenic diets continue to evolve, the options that are well-described in the literature are summarized below. For more information on each diet option and literature references see the expandable tabs following the diet table.

Research use Key dietary features Examples
“Western” purified atherogenic diet
Accelerated hypercholesterolemia and plaque formation in genetically modified models such as Apoe and Ldlr deficient mice.

Used for diet induced obesity in a variety of rodent models.
  • High fat diet (20 – 23% by weight; 40 – 45% kcal from fat)
  • Saturated fatty acids (SFA >60% of total fatty acids)
  • Milkfat/butterfat
  • Sucrose (34% by weight)
  • Cholesterol (0.2% total)
 TD.88137
TD.10885
“Western” purified atherogenic diet with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.

Will not promote obesity.
  • High fat diet (15 – 20% by weight; 34 – 45% kcal from fat)
  • Saturated fatty acids (SFA >55% of total fatty acids)
  • Milkfat/butterfat, cocoa butter
  • Sucrose (30-50% by weight)
  • Cholesterol (1 – 1.25%)
  • Cholate Source (0.5%)*
 TD.02028
TD.09237
Hybrid high fat diets with added cholesterol and cholate source*
Induce hypercholesterolemia and mild atherosclerosis (foam cells, fatty streaks) in primarily wild type mice and rats.

Will not promote obesity.

Also used for lithogenic (gallstone) rodent studies.
  • 75% rodent breeder diet; 25% purified ingredients
  • High fat (~15% by weight; 37% kcal from fat)
  • Saturated fatty acids (SFA >45% of total fatty acids)
  • Cholesterol (1.25%)
  • Cholate source (0.5%)*
 TD.88051
TD.90221
Standard diets with added cholesterol
Induce hypercholesterolemia in genetically modified and wild type models without promoting obesity.
  • Standard, grain-based rodent diet
  • Minimal/moderate phytoestrogen diets recommended
  • Cholesterol (1 – 4%)
 TD.120097
TD.07841
TD.01383

*Sodium cholate or cholic acid aid cholesterol and fat absorption and reduce cholesterol disposal via bile acid synthesis. However, if including a cholate source is not desired for your research, diets without cholate are available.

  • Diet induced obesity    饮食诱导肥胖
  • Fat/lipid adjusted   脂肪/脂调节
  • Carbohydrate adjusted    碳水化合物调节
  • Protein adjusted diets  蛋白质调节饮食
  • Vitamin adjusted diets  维生素调整饮食
  • Mineral adjusted diets  矿物调节饮食
  • NaCl adjusted (natural ingredient)  盐调节(天然成分)
  • Amino acid defined  氨基酸定义
  • Doxycycline diets  多西环素饮食
  • Tamoxifen diets  他莫昔芬饮食
  • Customer supplied ingredients  客户供应的配料
  • Basal mixes  基混合体
  • Isoflavone adjusted  异黄酮调节
  • Rabbit, swine and other species  兔子、猪和其他物种
  • Diet ingredients  饮食成分

Medicated diets  药物饮食

Teklad medicated lab animal diets are manufactured either at a subsidiary plant or at our custom research diet facility. Contact customer service or your local Envigo account representative for pricing and availability of stocked diets. Contact a nutritionist to discuss customized versions of these or other medicated diets.

Medicated diets must be used as directed by a veterinarian.

Stocked medicated rodent diets
Primary Purpose Product Code Medication Concentration Base diet Packaging
Fur mite treatment TD.130755 Ivermectin 12 ppm 2018 25 lb bag- irradiated
Pinworm treatment TD.01432 Fenbendazole 150 ppm 2018S 25 lb bag- irradiated*
50 lb bag- autoclavable
Pneumocystis pneumonia
prevention		 TD.06596 Uniprim® 275 ppm trimethoprim
1365 ppm sulfadiazine		 2018 25 lb bag- irradiate

Harlan Teklad TD.120240 Doxycycline饲料 40 ppm Doxy Diet (2018, B)

发表于由

Harlan Teklad TD.120240 Doxycycline饲料 40 ppm Doxy Diet (2018, B)

Harlan Teklad代理，欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。

Formula g/Kg
2018, Teklad Global 18% Protein Rodent Diet 999.704
Doxycycline Hyclate 0.046
Blue Food Color 0.25

Key Features

  • Standard Diet Base
  • 2018
  • Doxycycline
  • Color Coded Blue

Key Planning Information

  • Products are made fresh to order
  • Store product at 4°C or lower
  • Use within 6 months (applicable to most diets)
  • Box labeled with product name, manufacturing date, and lot number
  • Replace diet at minimum once per week  More frequent replacement may be advised
  • Lead time:    2 weeks non-irradiated     4 weeks irradiated

Footnote

Modification of TD.10483 to add blue coloring. Designed to add 40 mg doxycyline/kg diet using the Teklad 2018 Global Rodent Diet as the base. Doxycycline hyclate contains approximately 87% doxycycline.

Selected Nutrient Information1

% by weight % kcal from
Protein 18.2 22.9
Carbohydrate2 48.0 60.5
Fat 5.8 16.6
Kcal/g 3.2
  • Values are calculated from ingredient analysis or manufacturer data
  • Estimated digestible carbohydrate

Product Specific Information

  • 1/2″ Pellet or Powder (free flowing)
  • Minimum order 3 Kg
  • Irradiation available upon request

Options (Fees Will Apply)

  • Rush order (pending availability)
  • Irradiation (see Product Specific Information)
  • Vacuum packaging (1 and 2 Kg)

Harlan Teklad Medicated diets 药物饲料

发表于由

Harlan Teklad Medicated diets 药物饲料

Harlan Teklad代理，欢迎访问Harlan Teklad官网或者咨询我们获取更多相关产品信息。

Teklad medicated lab animal diets are manufactured either at a subsidiary plant or at our custom research diet facility. Contact customer service or your local Envigo account representative for pricing and availability of stocked diets. Contact a nutritionist to discuss customized versions of these or other medicated diets.

特克拉德药物实验室动物饮食是在一个附属工厂或在我们的定制研究饮食设施生产。与客户服务部门或当地Envigo客户代表联系，了解库存饮食的定价和供应情况。联系营养师讨论这些或其他药物饮食的定制版本。

Medicated diets must be used as directed by a veterinarian.

Stocked medicated rodent diets
Primary Purpose Product Code Medication Concentration Base diet Packaging
Fur mite treatment TD.130755 Ivermectin 12 ppm 2018 25 lb bag- irradiated
Pinworm treatment TD.01432 Fenbendazole 150 ppm 2018S 25 lb bag- irradiated*
50 lb bag- autoclavable
Pneumocystis pneumonia
prevention		 TD.06596 Uniprim® 275 ppm trimethoprim
1365 ppm sulfadiazine		 2018 25 lb bag- irradiated*

COLLAPSE ALL TABS

  • Testing shows very little medication loss due to manufacturing
  • Recommended storage at or below 70 degrees fahrenheit with humidity at or below 65%
  • Durable cylindrical pellets are visually distinct from flattened oval or extruded pellets (see picture)
  • 2018 supports growth and reproduction
  • 2018 is closely related to other Global Rodent Diets, and shares some commonality with traditional rodent diets

The anthelmintic ivermectin is used for the treatment of fur mites. TD.130755 (Irradiated 2018, 12 ppm Ivermectin) is stocked in 25 lb bags. Contact customer service regarding availability of TD.130755.

The anthelmintic fenbendazole is used for treatment of pinworms. TD.01432 (2018S, 150 ppm fenbendazole) is stocked in 25 lb bags that are irradiated or in 50 lb bags that can be autoclaved (note autoclaving reduces fenbendazole concentration and is only recommended if using to treat mice). Contact customer service regarding availability ofTD.01432.

Uniprim® contains trimethoprim and sulfadiazine, used to prevent occurrences of Pneumocystis pneumonia in immunocompromised mice and rats. TD.06596 (Irradiated 2018, 4100 ppm Uniprim®) is stocked in 25 lb bags. Contact customer service regarding availability of TD.06596.

Custom diets with Ivermectin, Uniprim®, and Fenbendazole are available. Modifications include: different base diet, coloring with food dyes, and other dosing concentrations based on your unique requirements. Contact a nutritionist to discuss your needs.

Other medications and compounds such as doxycycline and tamoxifen may be added to diets at our custom research diet facility. Visit our custom research diets site or contact us

药物饮食必须按照兽医的指示使用。

含药啮齿动物饲料
主要目的 产品代码 药物治疗 浓度 基础饮食 包装
毛螨处理 TD.130755 伊维菌素 百万分之十二 2018 25磅包-辐照
粉螨治疗 TD.01432 芬苯达唑 百万分之150 2008 S 25磅包-辐照*
50磅包-高压釜
肺孢子虫p肺炎
预防		 TD.06596 Uniprim® 275 ppm甲氧苄啶
1365 ppm磺胺嘧啶		 2018 25磅包-辐照*

COLLAPSE ALL TABS

  • 测试显示制造过程中药物损失很小。
  • 建议贮存温度在华氏70度或以下，湿度在65%或以下
  • 耐用的圆柱形球团在视觉上有别于扁平的椭圆形或挤压球团(见图)
  • 2018支持生长和繁殖
  • 2018与其他全球啮齿动物饮食密切相关，并与传统的啮齿动物饮食有一些共同之处

这个驱虫药伊维菌素用于治疗毛皮螨。TD.130755(辐照2018年，12 ppm伊维菌素)储存在25磅袋。与客户服务部门联系，了解TD.130755.

本发明为驱虫药芬苯达唑。TD.01432(2018S，150 ppm芬苯达唑)储存在25磅经辐照的袋子中，或装在50磅可被压的袋子中(注意，高压灭菌可以降低芬苯达唑的浓度，只有当用于治疗小鼠时才推荐使用)。与客户服务部门联系，了解TD.01432.

Uniprim®含有甲氧苄啶和磺胺嘧啶，用于预防免疫受损小鼠和大鼠肺炎肺孢子虫肺炎的发生。TD.06596(2018年辐照，4100 ppm Uniprim)®)装在25磅重的袋子里。与客户服务部门联系，了解TD.06596.

伊维菌素定制饮食®，芬苯达唑是可行的。修改包括：不同的基础饮食，染色与食物染料，以及其他剂量的浓度，根据您的独特要求。联系营养师来讨论你的需求。

其他药物和化合物，如强力霉素和他莫昔芬可以添加到我们的定制研究饮食设施的饮食。访问我们的定制研究饮食网站或联系我们以获得更多信息。

Harlan Teklad 他莫昔芬动物饲料 Tamoxifen diets

发表于由

Harlan Teklad 他莫昔芬动物饲料 Tamoxifen diets

Diets with tamoxifen activate CreER

Several references cite use of tamoxifen-containing diets for models with Cre under the control of a mutated estrogen receptor. Envigo Teklad diets makes a variety of tamoxifen-containing diets customized to meet your research needs. We also make a variety of doxycycline-containing diets for tet regulated systems. If you have any questions, don’t hesitate to consult a nutritionist.

Teklad stocks tamoxifen and tamoxifen citrate

Tamoxifen is added to the diet as a tamoxifen-sucrose mixture. Users are encouraged to use the stocked supply. However, Teklad will continue to work with customer prepared mixes. If you choose this option, please consult a nutritionist for additional information about preparing and sending the mixture.

Users are encouraged to select from the stocked options below supply readily available to ship within days.

Teklad offers diet with USP grade tamoxifen and tamoxifen citrate
Tamoxifen
mg per kg diet		 Daily tamoxifen
mg per kg body weight1		 Diet code
(Teklad supplied tamoxifen)
    Natural colored Red
250 40 TD.130855 TD.130856
500 80 TD.130857 TD.130858
400 citrate2 40 TD.130859 TD.1308603

1 Assumes 20-25 g body weight and three-four g intake
2 Tamoxifen citrate is 66% tamoxifen
3 Referred to as TAM400/CreER in Europe (TD.55125)

Please add 5-10 day lead time for irradiated diets; minimum 3 kg orders are required for stocked and customized items.

These diets all have tamoxifen premixed with ~five percent sucrose as a palatability enhancer; however, feed aversion may still occur. If intake is a problem, see below for advice.

Teklad Global 2016 — base diet in these examples — is only one of several minimal phytoestrogen diets Teklad produces. Consult a nutritionist about use of other base diets.

COLLAPSE ALL TABS

  • Minimum order quantity is three kg, sufficient for feeding ~20 mice for one month
  • Store diet refrigerated and plan to use within six months
  • Typical lead time is two weeks (four weeks if irradiated)
  • Irradiation (optional) minimal dose of 20 kGy (Must be requested at time of order)
  • To place an order: contact Teklad Customer Service at 800.483.5523 or initiate order online

Plan for:

  • Initial reduction in food intake and weight loss
  • Daily observation of animal tolerance — consult your IACUC for monitoring metrics
  • Intervene when necessary

If intake seems to be a problem:

  • Determine if a lower dose is effective for your model by conducting a tamoxifen dose feeding trial
  • Gradually acclimate mice by mixing tamoxifen-containing pellets with regular feed pellets
  • Wet the food, then place in a dish inside the cage (requires daily replacement)
  • Feed tamoxifen diet on weekdays, regular diet on weekends
  • Alternate weeks (two weeks on tamoxifen diet, one week off) for longer treatments
  • Tamoxifen is a selective estrogen receptor modulator (SERM) meaning it can repress actions of estrogen or have pro-estrogen effects
  • Usual dose for therapeutic effects in humans is 20 mg/day. Tamoxifen diets for rodents typically contain ~one to two mg/pellet
  • Accidental tamoxifen exposure can be minimized by using typical lab precautions of lab coat, gloves, and mask when handling the diet.
  • Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of tamoxifen containing diets.
  • Length of treatment varies from one to two weeks1,2,5,6,7,8 to one to two months3,4,8
  • Pure tamoxifen1,5,8 and tamoxifen citrate1,2,3,4,6,7 are both effective
  • Usual tamoxifen doses are ~40-80 mg per kg body weight per day
  • Typical inclusion for pure tamoxifen is 250 mg8 or 500 mg1,5 and for tamoxifen citrate is 400 mg per kg diet1,2,3,4,6,7
  • Initial weight loss of ten % is reported1,2,4,7,8, associated with reduced food intake2
  • Subsequent recovery of body weight after returning to regular diet may be compromised by gene inactivation2,7
  1. Andersson KB, Winer LH, Mork HK, Molkentin JD, Jaisser F. 2010. Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts. Transgenic Res 19:715-725.
  2. Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci USA 107:16320-16324.
  3. Kardakaris R, Gareus R, Xanthoulea S, Pasparakis M. 2011. Endothelial and macrophage-specific deficiency of P38alpha MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS One 6:e21055.
  4. Kiermayer C, Conrad M, Schneider M, Schmidt J, Brielmeier M. 2007. Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis 45:11-16.
  5. Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA. 2009. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res 105:12-15.
  6. Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, Mourkioti F. 2009. Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. PCirc Res 106:559-572.
  7. Miro-Murillo M, Elorza A, Soro-Arnaiz I, Albacete-Albacete L, Ordonez A, Balsa E, Vara-Vega A, Vazquez S, Fuertes E, Fernandez-Criado C, Landazuri MO, Aragones J. 2011. Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression. PLoS One 6:e22589.
  8. Welle S, Burgess K, Thornton CA, Tawil R. 2009. Relation between extent of myostatin depletion and muscle growth in mature mice. Am J Physiol Endocrinol Metab.Oct;297(4):E935-40.